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. Author manuscript; available in PMC: 2022 Feb 28.
Published in final edited form as: Lancet. 2018 Jun 29;392(10142):175–186. doi: 10.1016/S0140-6736(18)31128-0

Table 2:

Rotavirus and norovirus vaccine candidates in clinical trials in humans133, 134

Name, design, and target neutralisation antigens Vaccination route (features) Developer or manufacturer

Rotavirus
Clinical phase 3 Lanzhou lamb rotavirus reassortants; lamb rotavirus-based reassortants carrying human rotavirus antigens; and G2 to G4 specificity Oral (live attenuated) Lanzhou Institute of Biological Products, Lanzhou, China
Clinical phase 3 RotaShield; rhesus-human reassortant strains and tetravalent; and G1 to G4 specificity Oral (live attenuated) International Medica Foundation, Rochester, MN, USA
Clinical phase 3 UK-BRV tetravalent; and G1 to G4 specificity Oral (live attenuated) Shantha Biotech, Hyderabad, India
Clinical phase 2b RV3 neonatal strain; and G3P6 specificity Oral (live attenuated) Murdoch Children’s Research Institute, Parkville, VIC, Australia and PT Biofarma, Bandung, Indonesia
Clinical phase 2 Subunit; truncated VP4 protein; and P4, P6, and P8 specificity Intramuscular (subunit) PATH, Seattle, WA, USA
Clinical phase 1 UK-BRV reassortant; and G1 to G4, and G9 specificity Oral (live attenuated) Instituto Butantan, Sao Paulo, Brazil
Clinical phase 1 UK-BRV reassortant; and G1 to G4, G8, and G9 specificity Oral (live attenuated) Wuhan Institute of Biological Products, Wuhan, China and PATH, Seattle, WA, USA
Norovirus
Clinical phase 2b Norovirus virus-like particles; and GI.1 and GII.4 Intramuscular Takeda Vaccines, Cambridge, MA, USA
Clinical phase 1 Recombinant adenovirus expressing norovirus VP1; and GI.l Oral Vaxart, San Fransisco, CA, USA