Table 3: Lipid accumulation transcript analysis.
Gene | Cocktail | DMSO | SCO | ROSI |
---|---|---|---|---|
Cd36 | Vehicle | 0.0002±0.0003 | 0.02±0.007 | 0.36±0.24 p=0.013; $p=0.017 |
MDI | 0.56 ±0.12 | 2.69 ± 0.24 *p<0.0001 |
5.71 ± 0.50 *$p<0.0001 |
|
DI | 0.01 ± 0.004 | 0.88 ± 0.18 | 4.61 ± 2.53 *p=0.004; $p=0.014 |
|
D | 0.002 ± 0.0002 | 0.11 ± 0.02 | 1.33 ± 0.80 *p=0.007; $p=0.012 |
|
Srebf1 | Vehicle | 0.35 ± 0.03 | 0.48 ± 0.03 | 0.62 ± 0.15 *p=0.005 |
MDI | 1.30 ± 0.16 | 2.18 ± 0.21 *p=0.001 |
2.54 ± 0.29 *p<0.0001 |
|
DI | 0.60 ± 0.12 | 1.12 ± 0.13 *p=0.005 |
2.05 ± 0.23 *$p<0.0001 |
|
D | 0.65 ± 0.13 | D 0.96 ± 0.24 | 1.57 ± 0.07 *p<0.0001; $p=0.001 |
|
Fabp4 | Vehicle | 0.0001 ± 0.00003 | 0.004 ± 0.001 | 4.35 ± 0.15 *$p<0.0001 |
MDI | 0.20 ± 0.08 | 1.81 ± 0.40 *p=0.035 |
3.78 ± 1.23 *p=0.0002; $p=0.012 |
|
DI | 0.02 ± 0.005 | 0.47 ± 0.18 *p=0.016 |
0.84 ± 0.25 *p=0.0003; $p=0.037 |
|
D | 0.02 ± 0.003 | 0.09 ± 0.003 | 0.54 ± 0.60 | |
Lpl | Vehicle | 0.24 ± 0.03 | 0.40 ± 0.03 | 5.30 ± 1.49 *$p<0.0001 |
MDI | 1.36 ± 0.42 | 3.96 ± 0.42 *p<0.0001 |
4.71 ± 0.58 *p<0.0001 |
|
DI | 0.24 ± 0.04 | 1.06 ± 0.18 *p<0.0001 |
1.30 ± 0.13 *p<0.0001 |
|
D | 0.24 ± 0.03 | 0.40 ± 0.01 | 0.98 ± 0.51 *p=0.014; $p=0.048 |
|
Fasn | Vehicle | 0.12 ± 0.01 | 0.16 ± 0.02 *p=0.008 |
0.19 ± 0.01 *p=0.0002; $p=0.043 |
MDI | 1.25 ± 0.42 | 4.34 ± 0.88 *p=0.003 |
4.60 ± 1.25 *p=0.002 |
|
DI | 0.22 ± 0.01 | 0.56 ± 0.01 *p<0.0001 |
2.23 ± 0.11 *$p<0.0001 |
|
D | 0.25 ± 0.05 | 0.30 ± 0.01 | 0.72 ± 0.15 *p=0.0001; $p=0.0003 |
|
Glut4 | Vehicle | 0.002 ± 0.002 | 0.01 ± 0.01 | 16.35 ± 0.62 *$p<0.0001 |
MDI | 0.36 ± 0.26 | 6.06 ± 3.23 *p=0.016 |
6.53 ± 2.25 *p=0.01 |
|
DI | 0.01 ± 0.01 | 0.51 ± 0.23 *p=0.004 |
0.75 ±0.13 *p=0.0002 |
|
D | 0.01 ± 0.01 | 0.04 ± 0.01 | 0.37 ± 0.44 |
indicates significance compared to DMSO and $ indicates significance when comparing SCO and ROSI.