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. 2022 Feb 23;42(8):1587–1603. doi: 10.1523/JNEUROSCI.0407-21.2021

Figure 5.

Figure 5.

Age-associated genes in human astrocytes. Full expression data are presented in Extended Data Figure 5-1. A, Expression of age-associated human astrocyte genes with decreased expression in older adults (50+ years old) compared with younger adults (21-50 years old). Error bars indicate standard error. B, Age-associated human astrocyte genes with increased expression in older adults compared with younger adults. All genes shown are significantly associated with age, and at least 1.5-fold enriched in younger or older adults. Error bars indicate standard error. C, Change in RNA expression of mouse astrocytes (10 weeks old vs 2 years old) (Clarke et al., 2018) in various GO categories. Gene lists derived from the following GO annotations, from left to right: GO:0046034, GO:0045202, GO:0019221, and GO:0090398. D, Protein–protein interaction networks among human (top) and mouse (bottom) age-associated genes.