Table 4.
Levels of Antioxidant Enzymes and Products in Liver tissue of Control and Experimental rats.
| Parameters | Control | Cd Treated | Vit-C | Zinc | NAC | C + Zinc | C + NAC | Zinc + NAC | C + Zinc + NAC |
|---|---|---|---|---|---|---|---|---|---|
| MDA | 475 a ±25 PDC |
1015 b ±39 +114 |
885 b,c ±29 +86 |
901 b,c ±40 +90 |
950 b,c ±32 +100 |
809 b,c ±29 +70 |
804 b,c ±32 +69 |
775 b,c ±29 +64 |
670 b,c ±32 +41 |
| SOD | 66.79 a ±2.15 PDC |
31.73 b ±1.14 −35 |
34.44 b,c ±1.18 −48 |
36.18 b,c ±1.15 −46 |
38.14 b,c ±1.19 −43 |
40.12 b,c ±1.28 −40 |
42.14 b,c ±1.29 −37 |
44.75 b,c ±1.32 −33 |
51.14 b,c ±1.12 −23 |
| CAT | 88.14 a ±2.12 PDC |
42.44 b ±1.13 −52 |
44.75 b,c ±1.14 −49 |
47.75 b,c ±1.25 −46 |
49.75 b,c ±1.32 −43 |
53.72 b,c ±1.34 −40 |
59.14 b,c ±1.42 −37 |
60.19 b,c ±1.38 −33 |
68.13 b,c ±1.18 −23 |
| LPO | 5.14 a ±0.28 PDC |
9.85 b ±0.38 +92 |
8.35 b,c ±0.32 +63 |
8.19 b,c ±0.31 +59 |
7.74 b,c ±0.26 +51 |
7.15 b,c ±0.25 +39 |
6.74 b,c ±0.27 +31 |
6.34 b,c ±0.26 +23 |
6.15 b,c ±0.24 +20 |
| GPX | 8.15 a ±0.46 PDC |
4.05 b ±0.28 −50 |
4.18 b,c ±0.24 −49 |
4.34 b,c ±0.25 −47 |
4.75 b,c ±0.26 −42 |
5.25 b,c ±0.29 −36 |
5.79 b,c ±0.32 −29 |
6.42 b,c ±0.35 −22 |
7.04 b,c ±0.28 −14 |
| GSH | 4.93 a ±0.41 PDC |
2.85 b ±0.22 −42 |
2.92 b,c ±0.23 −41 |
2.94 b,c ±0.24 −40 |
3.02 b,c ±0.27 −39 |
3.14 b,c ±0.29 −36 |
3.25 b,c ±0.32 −34 |
3.32 b,c ±0.33 −33 |
3.49 b,c ±0.32 −29 |
Values are expressed as mean ± SD of six individual observations. a,b,c Values not sharing a common superscript letter (a,b,c) differ significantly at p < 0.05 (DMRT). PDC, percent deviation over control; MDA, µ moles/g wet wt of tissue; SOD, superoxide dismutase units/g wet weight of tissue/minute; CAT, catalase activity µ moles of H2O2 degladed/g wet wt of tissue/minute; LPO, µ moles of maloaldehyde formed/g wet weight; GPX, glutathione peroxidase nanomoles of NADPH oxidized/mg protein/minute; GSH, glutathione nanomoles/g wet weight of tissue.