| Study |
Time |
Treatment |
Outcome |
N of Pts |
Baseline Mean |
End of Study Mean |
Absolute Benefit |
Relative Difference |
| Lohmander 1996 |
1‐4 wk |
E: Artzal |
Pain (0‐100 mm VAS) |
96 |
49.76 |
36.64 |
2.48 (W) |
5.2% (W) |
| |
|
C: Saline |
|
93 |
47.84 |
32.24 |
|
|
| Lohmander 1996 |
5‐13 wk |
E: Artzal |
Pain (0‐100 mm VAS) |
96 |
49.76 |
34.69 |
‐2.46 (I) |
‐5.1% (I) |
| |
|
C: Saline |
|
93 |
47.84 |
35.23 |
|
|
| Lohmander 1996 |
14‐26 wk |
E: Artzal |
Pain (0‐100 mm VAS) |
96 |
49.76 |
33.65 |
‐3.67 (I) |
‐7.7% (I) |
| |
|
C: Saline |
|
93 |
47.84 |
35.40 |
|
|
| Lohmander 1996 |
1‐4 wk |
E: Artzal |
Activity level (0‐100 mm VAS) |
96 |
62.98 |
43.69 |
4.77 (W) |
7.4% (W) |
| |
|
C: Saline |
|
93 |
64.71 |
40.65 |
|
|
| Lohmander 1996 |
5‐13 wk |
E: Artzal |
Activity level (0‐100 mm VAS) |
96 |
62.98 |
45.17 |
4.71 (W) |
7.3% (W) |
| |
|
C: Saline |
|
93 |
64.71 |
42.19 |
|
|
| Lohmander 1996 |
14‐26 wk |
E: Artzal |
Activity level (0‐100 mm VAS) |
96 |
62.98 |
41.67 |
‐0.68 (I) |
‐1.1% (I) |
| |
|
C: Saline |
|
93 |
64.71 |
44.08 |
|
|
| Lohmander 1996 |
14‐26 wk |
E: Artzal |
Lequesne (0‐24) |
120 |
9.89 |
7.98 |
‐0.17 (I) |
‐1.8% (I) |
| |
|
C: Saline |
|
120 |
9.56 |
7.82 |
|
|
| Lohmander 1996 |
1‐4 wk |
E: Artzal |
Knee function (0‐100 mm VAS) |
96 |
53.76 |
38.00 |
2.17 (W) |
4.1% (W) |
| |
|
C: Saline |
|
93 |
53.02 |
35.09 |
|
|
| Lohmander 1996 |
5‐13 wk |
E: Artzal |
Knee function (0‐100 mm VAS) |
96 |
53.76 |
42.34 |
4.09 (W) |
7.7% (W) |
| |
|
C: Saline |
|
93 |
53.02 |
37.51 |
|
|
| Lohmander 1996 |
14‐26 wk |
E: Artzal |
Knee function (0‐100 mm VAS) |
96 |
53.76 |
38.27 |
‐2.3 (I) |
‐4.3% (I) |
| |
|
C: Saline |
|
93 |
53.02 |
39.83 |
|
|
| Karlsson 2002a |
1‐4 wk |
E: Artzal |
Pain on weight bearing (0‐100 mm VAS) |
92 |
64 |
44 |
1.0 (W) |
1.5% (W) |
| |
|
C: Saline |
|
66 |
65 |
44 |
|
|
| Karlsson 2002a |
5‐13 wk |
E: Artzal |
Pain on weight bearing (0‐100 mm VAS) |
92 |
64 |
42 |
‐3 (I) |
‐4.6% (I) |
| |
|
C: Saline |
|
66 |
65 |
46 |
|
|
| Karlsson 2002a |
14‐26 wk |
E: Artzal |
Pain on weight bearing (0‐100 mm VAS) |
92 |
64 |
48 |
5 (W) |
7.7% (W) |
| |
|
C: Saline |
|
66 |
65 |
44 |
|
|
| Karlsson 2002a |
5‐13 wk |
E: Artzal |
WOMAC (0‐100 mm VAS) |
92 |
48.7 |
34.7 |
4.2 (W) |
8.6% (W) |
| |
|
C: Saline |
|
66 |
48.9 |
30.7 |
|
|
| Karlsson 2002a |
14‐26 wk |
E: Artzal |
WOMAC (0‐100 mm VAS) |
92 |
48.7 |
37.4 |
5.5 (W) |
11.2% (W) |
| |
|
C: Saline |
|
66 |
48.9 |
32.1 |
|
|
| Karlsson 2002a |
14‐26 wk |
E: Artzal |
Lequesne Index (0‐24) |
92 |
13.9 |
10.0 |
0.8 (W) |
5.9% (W) |
| |
|
C: Saline |
|
66 |
13.6 |
8.9 |
|
|
| Puhl 1993 |
1‐4 wk |
E: Artz |
Pain (0‐100 mm VAS) |
95 |
54.10 |
29.14 |
‐4.96 (I) |
‐9.6% (I) |
| |
|
C: Vehicle |
|
100 |
51.40 |
31.40 |
|
|
| Puhl 1993 |
5‐13 wk |
E: Artz |
Pain (0‐100 mm VAS) |
95 |
54.10 |
26.50 |
‐10.2 (I) |
‐19.8 (I) |
| |
|
C: Vehicle |
|
100 |
51.40 |
34.00 |
|
|
| Puhl 1993 |
1‐4 wk |
E: Artz |
Lequesne Index (0‐24) |
95 |
10.4 |
7.19 |
‐0.81 (I) |
‐8.6% (I) |
| |
|
C: Vehicle |
|
100 |
9.4 |
7.00 |
|
|
| Puhl 1993 |
5‐13 wk |
E: Artz |
Lequesne Index (0‐24) |
95 |
10.4 |
6.43 |
‐1.36 (I) |
‐14.5% (I) |
| |
|
C: Vehicle |
|
100 |
9.4 |
6.79 |
|
|
| Shichikawa 1983b |
1‐4 wk |
E: Artz |
Pain (0‐3) |
52 |
1.03 |
0.66 |
0.02 (W) |
1.8% (W) |
| |
|
C: Vehicle |
|
55 |
1.12 |
0.73 |
|
|
| Shichikawa 1983b |
1‐4 wk |
E: Artz |
Range of motion (flexion degrees) |
52 |
133.4 |
135.65 |
‐1.75 (W) |
‐1.4% (W) |
| |
|
C: Vehicle |
|
55 |
128.6 |
132.60 |
|
|
| Day 2004 |
5‐13 wk |
E: Artz |
WOMAC pain (0‐20 Likert) |
116 |
7.96 |
3.84 |
‐0.05 (I) |
‐0.6% (I) |
| |
|
C: Saline |
|
124 |
8.68 |
4.61 |
|
|
| Day 2004 |
|
E: Artz |
WOMAC function (0‐68 Likert) |
116 |
28.07 |
11.41 |
4.06 (W) |
13% (W) |
| |
|
C: Saline |
|
124 |
31.25 |
10.53 |
|
|
| Day 2004 |
|
E: Artz |
WOMAC stiffness (0‐8) |
116 |
3.70 |
1.42 |
0.07 (W) |
1.8% (W) |
| |
|
C: Saline |
|
124 |
3.79 |
1.44 |
|
|
