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. 2006 Apr 19;2006(2):CD005321. doi: 10.1002/14651858.CD005321.pub2

17. Clinical benefit table: Hyalgan versus placebo. Continuous outcome measures (2).

Study Time Treatment Outcome (scale) N of Pts Baseline Mean End of Study Mean Absolute Benefit Relative Difference
Altman 1998 1‐4 wk E: Hyalgan Pain after walking 50 feet (0‐100 mm VAS) 163 54 25 1 (W) 1.8% (W)
    C: Saline   167 55 25    
Altman 1998 5‐13 wk E: Hyalgan Pain after walking 50 feet (0‐100 mm VAS) 163 54 23 0 0
    C: Saline   167 55 24    
Altman 1998 14‐26 wk E: Hyalgan Pain after walking 50 feet (0‐100 mm VAS) 163 54 18 ‐2 (I) ‐3.6% (I)
    C: Saline   167 55 21    
Dougados 1993 1‐4 wk E: Hyalectin Pain on movement (0‐100 mm VAS) 52 67.85 34.13 ‐7.52 (I) ‐12.16% (I)
    C: Saline   50 61.82 35.62    
Dougados 1993 45‐52 wk E: Hyalectin Pain on movement (0‐100 mm VAS) 47 67.85 28.51 ‐6.87(I) ‐11.11% (I)
    C: Saline   48 61.82 29.35    
Carrabba 1995 1‐4 wk E: Hyalgan (5) Pain at rest (0‐100 mm VAS) 20 43.6 28.3 ‐7.1 (I) ‐15.6% (I)
    C: Saline   20 45.6 37.4    
Carrabba 1995a 1‐4 wk E: Hyalgan (3) Pain at rest (0‐100 mm VAS) 20 44.7 30.3 ‐6.2 (I) ‐13.6% (I)
    C: Saline   20 45.6 37.4    
Carrabba 1995b 1‐4 wk E: Hyalgan (5) Pain at rest (0‐100 mm VAS) 20 43.6 28.3 ‐12.4 (I) ‐28.6% (I)
    C: Arthrocentesis   20 43.3 40.4    
Carrabba 1995c 1‐4 wk E: Hyalgan (3) Pain at rest (0‐100 mm VAS) 20 44.7 30.3 ‐11.5 (I) ‐26.6% (I)
    C: Arthrocentesis   20 43.3 40.4    
Corrado 1995 1‐4 wk E: Hyalgan Pain at rest (0‐100 mm VAS) 19 22.5 9.4 ‐8.5 (I) ‐62% (I)
    C: Saline   16 13.7 9.1    
Dougados 1993 1‐4 wk E: Hyalectin Pain at rest (0‐100 mm VAS) 52 31.44 10.87 ‐7.72 (I) ‐28.03% (I)
    C: Saline   48 27.54 14.69    
Henderson 1994 1‐4 wk E: Hyalgan Pain at rest (0‐100 mm VAS) 18 20.8 17.7 ‐4.1 (I) ‐13.5% (I)
    C: Saline   19 30.3 31.3    
Henderson 1994a 1‐4 wk E: Hyalgan Pain at rest (0‐100 mm VAS) 22 25.2 25.3 15 (W) 38.5% (W)
    C: Saline   25 38.9 24.0    
Carrabba 1995 5‐13 wk E: Hyalgan (5) Pain at rest (0‐100 mm VAS) 20 43.6 29.3 ‐8.6 (I) ‐18.9% (I)
    C: Saline   20 45.6 39.9    
Carrabba 1995a 5‐13 wk E: Hyalgan (3) Pain at rest (0‐100 mm VAS) 20 44.7 33.0 ‐6 (I) ‐13.2% (I)
    C: Saline   20 45.6 39.9    
Carrabba 1995b 5‐13 wk E: Hyalgan (5) Pain at rest (0‐100 mm VAS) 20 43.6 29.3 ‐14.2 (I) ‐32.8% (I)
    C: Arthrocentesis   20 43.3 43.2    
Carrabba 1995c 5‐13 wk E: Hyalgan (3) Pain at rest (0‐100 mm VAS) 20 44.7 33.0 ‐11.6 (I) ‐26.8% (I)
    C: Arthrocentesis   20 43.3 43.2    
Corrado 1995 5‐13 wk E: Hyalgan Pain at rest (0‐100 mm VAS) 19 22.5 5.1 ‐15.9 (I) ‐116.1% (I)
    C: Saline   16 13.7 12.2    
Dougados 1993 45‐52 wk E: Hyalectin Pain at rest (0‐100 mm VAS) 47 31.44 11.87 ‐1.68 (I) ‐6.10% (I)
    C: Saline   48 27.54 9.65    
Henderson 1994 1‐4 wk E: Hyalgan Pain at night (0‐100 mm VAS) 18 69.6 45.50 ‐10.3 (I) ‐15.1% (I)
    C: Saline   19 68.0 54.20    
Henderson 1994a 1‐4 wk E: Hyalgan Pain at night (0‐100 mm VAS) 22 68.3 60.20 4.4 (W) 6% (W)
    C: Saline   25 73.3 60.80    
Corrado 1995 1‐4 wk E: Hyalgan Flexion (degrees) 19 114.7 123.5 2.1 (I) 1.9% (I)
    C: Saline   16 113.3 120.0    
Corrado 1995 5‐13 wk E: Hyalgan Flexion (degrees) 19 114.7 125.5 6.2 (I) 5.5% (I)
    C: Saline   16 113.3 117.9    
Corrado 1995 1‐4 wk E: Hyalgan Synovial fluid volume (ml) 21 20.3 14.10 ‐2.3 (I) ‐15% (I)
    C: Saline   19 15.3 11.40    
Dougados 1993 1‐4 wk E: Hyalectin Synovial fluid volume (ml) 55 18.5 6.10 ‐6.4 (I) ‐46% (I)
    C: Saline   55 13.9 7.90    
Corrado 1995 5‐13 wk E: Hyalgan Synovial fluid volume (ml) 21 20.3 2.30 ‐13.1 (I) ‐85.6% (I)
    C: Saline   19 15.3 10.40    
Jubb 2001a 45‐52 wk E: Hyalgan Joint space width (mm) 136 4.9 4.80 0 0
    C: Saline   137 4.5 4.40    
Jubb 2001b 45‐52 wk E: Hyalgan Joint space width (mm) 76 5.9 5.80 0.4 (I) 6.8% (I)
    C: Saline   63 5.9 5.40    
Jubb 2001c 45‐52 wk E: Hyalgan Joint space width (mm) 60 3.5 3.50 ‐0.2 (W) ‐5.9% (W)
    C: Saline   74 3.4 3.60    
St. J. Dixon 1988 1‐4 wk E: Hyalgan Pain on movement (0‐100 mm VAS) 28 66.52 50.54 ‐14.13 (I) ‐21.17% (I)
    C: Vehicle   33 66.76 64.91    
St. J. Dixon 1988 45‐52 wk (repeat) E: Hyalgan Pain on movement (0‐100 mm VAS) 11 66.52 48.45 ‐8.31(I) ‐12.45% (I)
    C: Vehicle   13 66.76 57.00    
St. J. Dixon 1988 1‐4 wk E: Hyalgan Pain at rest (0‐100 mm VAS) 29 30.86 20.50 ‐11.61 (I) ‐54.28% (I)
    C: Vehicle   33 21.39 22.64    
St. J. Dixon 1988 45‐52 wk (repeat) E: Hyalgan Pain at rest (0‐100 mm VAS) 11 30.86 25.36 ‐4.97 (I) ‐23.24% (I)
    C: Vehicle   14 21.39 20.86