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. 2006 Apr 19;2006(2):CD005321. doi: 10.1002/14651858.CD005321.pub2

28. Clinical benefit table: Hylan G‐F 20 versus placebo. Continuous outcome measures.

Study Time Treatment group Outcome (scale) N of Pts Baseline Mean End of Study Mean Absolute Benefit Relative Difference
Scale 1994a 5‐13 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 25 61 27 ‐20 (I) ‐29.9% (I)
    C: Saline   25 67 53    
Scale 1994a 5‐13 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 25 29 16 ‐13 (I) ‐50.0% (I)
    C: Saline   25 26 26    
Scale 1994b 5‐13 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 15 65 11 ‐27 (I) ‐38.6% (I)
    C: Saline   15 70 43    
Scale 1994b 5‐13 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 15 30 2 ‐10 (I) ‐30.3% (I)
    C: Saline   15 33 15    
Wobig 1998 5‐13 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 57 70 23 ‐32 (I) ‐42.7% (I)
    C: Saline   60 75 60    
Wobig 1998 5‐13 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 57 41 12 ‐13 (I) ‐28.3% (I)
    C: Saline   60 46 30    
Wobig 1999 5‐13 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 38 70 32 ‐1 (I) ‐1.3% (I)
    C: Nonelastoviscous Hylan G‐F 20   36 80 43    
Wobig 1999 5‐13 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 38 26 13 2 (W) 7.4% (W)
    C: Nonelastoviscous Hylan G‐F 20   36 27 12    
Moreland 1993 1‐4 wk E: Hylan GF 20 Pain on motion (0‐100 mm VAS) 46 69 47 ‐3 (I) ‐4.3% (I)
    C: Arthrocentesis   48 70 51    
Moreland 1993 1‐4 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 46 60 36 6 (W) 8% (W)
    C: Arthrocentesis   48 75 45    
Moreland 1993 1‐4 wk E: Hylan GF 20 Pain at rest (0‐100 mm VAS) 46 61 39 ‐2 (I) ‐3.1% (I)
    C: Arthrocentesis   48 64 44    
Moreland 1993 1‐4 wk E: Hylan G‐F 20 Pain walking (0‐100 mm VAS) 46 79 57 ‐2 (I) ‐2.5% (I)
    C: Arthrocentesis   48 80 60    
Moreland 1993 1‐4 wk E: Hylan GF 20 Pain overall (0‐100 mm VAS) 46 78 55 ‐2 (I) ‐2.6% (I)
    C: Arthrocentesis   48 78 57    
Dickson 2001 5‐13 wk E: Hylan G‐F 20 WOMAC pain (0‐100 mm VAS) 53 59 26 ‐9 (I) ‐15.5% (I)
    C: Arthrocentesis + Placebo capsules   57 58 34    
Dickson 2001 5‐13 wk E: Hylan G‐F 20 WOMAC function (0‐100 VAS) 53 54 38 ‐7 (I) ‐12.5% (I)
    C: Arthrocentesis + Placebo capsules   57 56 47    
Dickson 2001 5‐13 wk E: Hylan G‐F 20 Lequesne Index (0‐24) 53 13.9 10.9 ‐1 (I) ‐6.9% (I)
    C: Arthrocentesis + Placebo capsules   57 14.5 12.5    
Karlsson 2002b 1‐4 wk E: Hylan G‐F 20 Pain on weight bearing (0‐100 mm VAS) 88 63 45 3.0 (W) 4.6% (W)
    C: Saline   66 65 44    
Karlsson 2002b 5‐13 wk E: Hylan G‐F 20 Pain on weight bearing (0‐100 mm VAS) 88 63 41 ‐3.0 (I) ‐4.6% (I)
    C: Saline   66 65 46    
Karlsson 2002b 14‐26 wk E: Hylan G‐F 20 Pain on weight bearing (0‐100 mm VAS) 88 63 43 1.0 (W) 1.5% (W)
    C: Saline   66 65 44    
Karlsson 2002b 5‐13 wk E: Hylan G‐F 20 WOMAC (0‐100 mm VAS) 88 48.7 31.7 1.2 (W) 2.5% (W)
    C: Saline   66 48.9 30.7    
Karlsson 2002b 14‐26 wk E: Hylan G‐F 20 WOMAC (0‐100 mm VAS) 88 48.7 31.9 ‐1.0 (I) ‐2.0% (I)
    C: Saline   66 48.9 33.1    
Karlsson 2002b 14‐26 wk E: Hylan G‐F 20 Lequesne Index (0‐24) 88 13.4 9.0 0.3 (W) 2.2% (W)
    C: Saline   66 13.6 8.9    
Scale 1994a 14‐26 wk E: Hylan G‐F 20 Pain on weight bearing (0‐100 mm VAS) 15 61 18 ‐33 (I) ‐49.3 (I)
    C: Saline   21 67 57    
Scale 1994a 14‐26 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 15 29 10 ‐25 (I) ‐96.2 (I)
    C: Saline   21 26 32    
Scale 1994b 14‐26 wk E: Hylan G‐F 20 Pain on weight bearing (0‐100 mm VAS) 15 65 22 ‐18 (I) ‐25.7 (I)
    C: Saline   15 70 45    
Scale 1994b 14‐26 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 15 30 3 ‐10 (I) ‐30.3 (I)
    C: Saline   15 33 16    
Wobig 1998 14‐26 wk E: Hylan G‐F 20 Pain on weight bearing (0‐100 mm VAS) 56 70 35 ‐16 (I) ‐21.3 (I)
    C: Saline   60 75 56    
Wobig 1998 14‐26 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 56 41 16 ‐13 (I) ‐28.3% (I)
    C: Saline   60 46 34    
Scale 1994a 1‐4 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 25 61 32 ‐9 (I) ‐13.4% (I)
    C: Saline   25 67 47    
Scale 1994a 1‐4 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 25 29 18 ‐8 (I) ‐30.8% (I)
    C: Saline   25 26 23    
Scale 1994b 1‐4 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 15 65 22 ‐17 (I) ‐24.3% (I)
    C: Saline   15 70 44    
Scale 1994b 1‐4 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 15 30 7 ‐7 (I) ‐21.2% (I)
    C: Saline   15 33 17    
Wobig 1998 1‐4 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 57 70 31 ‐17 (I) ‐22.7% (I)
    C: Saline   60 75 53    
Wobig 1998 1‐4 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 57 41 15 ‐6 (I) ‐13.0% (I)
    C: Saline   60 46 26    
Wobig 1999 1‐4 wk E: Hylan G‐F 20 Weight bearing pain (0‐100 mm VAS) 38 70 40 ‐3 (I) ‐3.8% (I)
    C: Saline   36 80 53    
Wobig 1998 1‐4 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 38 26 12 1 (W) 3.7% (W)
    C: Saline   36 27 12    
Cubukcu 2004 1‐4 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 20 45 27    
    C: Saline   10 54 37    
Cubukcu 2004 5‐13 wk E: Hylan G‐F 20 Pain at night (0‐100 mm VAS) 20 45 23    
    C: Saline   10 54 44    
Cubukcu 2004 1‐4 wk E: Hylan G‐F 20 Pain at rest (0‐100 mm VAS) 20 47 29    
    C: Saline   10 51 39    
Cubukcu 2004 5‐13 wk E: Hylan G‐F 20 Pain at rest (0‐100 mm VAS) 20 47 22    
    C: Saline   10 51 41    
Cubukcu 2004 1‐4 wk E: Hylan G‐F 20 Pain walking (0‐100 mm VAS) 20 71 47    
    C: Saline   10 67 51    
Cubukcu 2004 5‐13 wk E: Hylan G‐F 20 Pain walking (0‐100 mm VAS) 20 71 40    
    C: Saline   10 67 54    
Cubukcu 2004 1‐4 wk E: Hylan G‐F 20 Need for paracetamol (pill count) 20 1.0 0.0    
    C: Saline   10 0.9 0.1    
Cubukcu 2004 5‐13 wk E: Hylan G‐F 20 Need for paracetamol (pill count) 20 1.0 0.0    
    C: Saline   10 0.9 0.7    
Cubukcu 2004 1‐4 wk E: Hylan G‐F 20 WOMAC pain (5‐25) 20 16 11    
    C: Saline   10 18 14    
Cubukcu 2004 5‐13 wk E: Hylan G‐F 20 WOMAC pain (5‐25) 20 16 9    
    C: Saline   10 18 15    
Cubukcu 2004 1‐4 wk E: Hylan G‐F 20 WOMAC function (17‐85) 20 50 41    
    C: Saline   10 48 47    
Cubukcu 2004 5‐13 wk E: Hylan G‐F 20 WOMAC function (17‐85) 20 50 36    
    C: Saline   10 48 47