Skip to main content
. 2006 Apr 19;2006(2):CD005321. doi: 10.1002/14651858.CD005321.pub2

52. Effect size based on Standardised Mean Difference ‐ Part I.

Product Comparison Outcome 1‐4 wk 5‐13 wk 14‐26 wk 45‐52 wk
Artz, Artzal Placebo Pain (VAS) 0.02 (‐0.16,0.20) P value 0.8 ‐0.19 (‐0.37,‐0.01) P value 0.04 0.00 (‐0.24,0.23) P value 1  
    Pain (0‐3) ‐0.14 (‐0.54,0.26) P value 0.5      
    WOMAC pain (Likert)   ‐0.24 (‐0.50,0.02) P value 0.07    
    WOMAC function (Likert)   ‐0.22 (‐0.49,0.04) P value 0.10    
    WOMAC stiffness (Likert)   ‐0.24 (‐0.51,0.02) P value 0.07    
    Lequesne Index (0‐24) 0.06 (‐0.23,0.34) P value 0.7 ‐0.11 (‐0.39,0.17) P value 0.5 0.11 (‐0.09,0.31) P value 0.3  
    Range of motion (degrees) 0.22 (‐0.18,0.61) P value 0.3      
  Hylan G‐F 20 Pain weight bearing (VAS) ‐0.04 (‐0.34,0.26) P value 0.8 0.03 (‐0.26,0.33) P value 0.8 0.15 (‐0.15,0.44) P value 0.3  
    Lequesne Index (0‐24)     0.21 (‐0.08,0.50) P value 0.16  
BioHy (Arthrease) Hylan G‐F 20 WOMAC pain (VAS) ‐0.18 (‐0.40,0.04) P value 0.10 ‐0.19 (‐0.41,0.03) P value 0.08    
Fermathron Hyalart Pain (VAS) 0.11 (‐0.14,0.37) P value 0.4 0.04 (‐0.22,0.30) P value 0.8    
    Lequesne Index (0‐24) 0.11 (‐0.14,0.37) P value 0.4 0.14 (‐0.12,0.39) P value 0.3    
Hyalgan Placebo Pain weight bearing (VAS) ‐0.32 (‐0.58,‐0.05) P value 0.02 ‐0.41 (‐0.66,‐0.16) P value 0.001 ‐0.22 (‐0.43,‐0.02) P value 0.03 ‐0.07 (‐0.24,0.10) P value 0.4
    Pain spontaneous (VAS) ‐1.14 (‐1.64,‐0.64) P value 0.00001 ‐1.07 (‐1.56,‐0.57) P value 0.00003    
    Pain at rest (VAS) ‐0.49 (‐0.88,‐0.10) P value 0.01 ‐0.72 (‐1.06,‐0.38) P value 0.00004   0.07 (‐0.29,0.43) P value 0.7
    Pain at night (VAS) ‐0.69 (‐1.88,0.50) P value 0.3      
    WOMAC pain (VAS) ‐0.18 (‐0.47,0.10) P value 0.2 ‐0.10 (‐0.40,0.19) P value 0.5 ‐0.38 (‐0.68,‐0.08) P value 0.01  
    WOMAC function (VAS) ‐0.09 (=0.37,0.20) P value 0.5 ‐0.07 (‐0.37,0.22) P value 0.6 ‐0.28 (‐0.57,0.02) P value 0.07  
    Lequesne Index (0‐24) ‐0.39 (‐0.63,‐0.16) P value 0.0010 ‐0.60 (‐0.89,‐0.31) P value 0.00006 ‐0.30 (‐0.74,0.14) P value 0.18 ‐0.28 (‐0.69,0.13) P value 0.18
    Flexion (degrees) 0.30 (‐0.37,0.97) P value 0.4 0.70 (0.01,1.39) P value 0.05    
    Synovial fluid volume (ml) ‐0.07 (‐0.39,0.24) P value 0.6 ‐0.51 (‐1.02,‐0.01) P value 0.04    
    Joint space width (total population)       0.26 (0.02,0.49) P value 0.04
    Joint space width (subgroups)       0.12 (‐0.28,0.52) P value 0.6
  Arthroscopy Pain (VAS) 0.42 (‐0.31,1.15) P value 0.3 0.00 (‐0.70,0.70) P value 1 ‐0.25 (‐1.00,0.49) P value 0.5 0.00 (‐0.79,0.79) P value 1
    Knee Society Function Scale 0.53 (‐0.21,1.26) P value 0.16 0.49 (‐0.23,1.21) P value 0.18 0.77 (0.00,1.54) P value 0.05 0.72 (‐0.10,1.54) P value 0.08
    Lequesne Index (0‐24) 0.53 (‐0.21,1.26) P value 0.16 0.49 (‐0.23,1.21) P value 0.18 0.77 (0.00,1.54) P value 0.05 0.72 (‐0.10,1.54) P value 0.08
  NSAID Pain after 50 foot walk (VAS) 0.00 (‐0.23,0.23) P value 1 0.08 (‐0.17,0.33) P value 0.5 ‐0.13 (‐0.40,0.14) P value 0.3  
  Methylprednisolone acetate Spontaneous pain intensity (VAS) ‐0.27 (‐0.58,0.03) P value 0.08 ‐0.41 (‐0.90,0.08) P value 0.10   0.10 (‐0.60,0.79) P value 0.8
    Range of motion (degrees) 0.39 (0.05,0.74) P value 0.03 0.40 (0.05,0.75) P value 0.02   0.07 (‐0.62,0.77) P value 0.8
  Triamcinolone hexacetonide Pain on nominated activity (VAS) ‐0.01 (‐0.53,0.52) P value 1 (end of treatment)   ‐0.39 (‐1.29,0.52) P value 0.4  
    Pain at rest (VAS) ‐0.02 (‐0.54,0.50) P value 0.9 (end of treatment)   ‐0.76 (‐1.69,0.18) P value 0.11  
    Pain at night (VAS) ‐0.21 (‐0.74,0.31) P value 0.4 (end of treatment)   ‐1.11 (‐2.09,‐0.14) P value 0.03  
  Mucopolysaccharide polysulfuric acid ester Pain (0‐30) 0.66 (0.14,1.19) P value 0.01 (end of treatment)      
    Function (0‐30) 0.11 (‐0.40,0.63) P value 0.7 (end of treatment)      
    Range of motion (0‐10) 0.39 (‐0.13,0.91) P value 0.14 (end of treatment)      
    Total Larson rating score (0‐77) 0.63 (0.10,1.16) P value 0.02 (end of treatment)      
  Appropriate care Pain overall (VAS)       ‐0.53 (‐1.20,0.14) P value 0.12
    Lequesne Index (0‐24)       ‐0.20 (‐0.85,0.46) P value 0.6
    Joint space width (mm)       0.63 (‐0.04,1.30) P value 0.07
    Quality of life: AIMS       ‐0.16 (‐0.82,0.49) P value 0.6
    Arthroscopy overall score (VAS)       ‐0.79 (‐1.47,‐0.10) P value 0.02
    SFA score (VAS)       ‐0.90 (‐1.59,‐0.21) P value 0.01
Hylan G‐F 20 Placebo Pain weight bearing (VAS) ‐0.51 (‐0.87,‐0.15) P value 0.006 ‐0.94 (‐1.57,‐0.31) P value 0.003 ‐0.77 (‐1.38,‐0.15) P value 0.01  
    Pain at night (VAS) ‐0.30 (‐0.50,‐0.09) P value 0.005 ‐0.52 (‐1.00,‐0.05) P value 0.03 ‐0.82 (‐1.12,‐0.51) p<0.00001  
    WOMAC pain (VAS)   ‐0.31 (‐0.68,0.07) P value 0.11    
    Pain at rest (VAS) ‐0.14 (‐0.55,0.26) P value 0.5      
    Pain overall (VAS) ‐0.07 (‐0.48,0.33) P value 0.7      
    Lequesne Index (0‐24)     0.02 (‐0.30,0.34) P value 0.9  
    WOMAC function (VAS)   ‐0.43 (‐0.81,‐0.05) P value 0.03    
    Function: improvement (VAS) 0.63 (0.39,0.88) p<0.00001 1.29 (0.97,1.60) p<0.00001    
    Patient global: treatment efficacy (VAS) 0.72 (0.47,0.96) p<0.00001 1.19 (0.66,1.71) P value 0.00001    
  NSAID Pain on motion (VAS)   ‐0.27 (‐0.80,0.25) P value 0.3 ‐0.49 (‐1.02,0.03) P value 0.07  
    Pain at rest (VAS)   ‐0.14 (‐0.66,0.39) P value 0.6 ‐0.15 (‐0.67,0.36) P value 0.6  
    Pain at night (VAS)   ‐0.29 (‐0.82,0.23) P value 0.3 ‐0.12 (‐0.64,0.39) P value 0.6  
    Pain overall (VAS)   ‐0.18 (‐0.71,0.34) P value 0.5 ‐0.23 (‐0.75,0.29) P value 0.4  
    WOMAC pain (VAS)   ‐0.41 (‐0.79,‐0.02) P value 0.04    
    WOMAC function (VAS)   ‐0.21 (‐0.59,0.16) P value 0.3    
    Lequesne Index (0‐24)   ‐0.27 (‐0.65,0.11) P value 0.16    
Hylan G‐F 20 + NSAID NSAID Pain on motion (VAS)   ‐0.44 (‐0.93,0.06) P value 0.08 ‐0.66 (‐1.17,‐0.15) P value 0.01  
    Pain at rest (VAS)   ‐0.44 (‐0.93,0.06) P value 0.08 ‐0.66 (‐1.17,‐0.15) P value 0.01  
    Pain at night (VAS)   ‐0.48 (‐0.98,0.02) P value 0.06 ‐0.84 (‐1.35,‐0.32) P value 0.002  
    Pain overall (VAS)   ‐0.46 (‐0.96,0.03) P value 0.07 ‐0.66 (‐1.17,‐0.15) P value 0.01  
Hylan G‐F 20 Triamcinolone hexacetonide WOMAC pain Q1 (Likert)   ‐0.43 (‐0.70,‐0.16) P value 0.002 ‐0.38 (‐0.65,‐0.11) P value 0.005  
    WOMAC function (Likert)   ‐0.35 (‐0.62,‐0.08) P value 0.01 ‐0.36 (‐0.63,‐0.09) P value 0.010  
    WOMAC total score (Likert)   ‐0.37 (‐0.64,‐0.10) P value 0.007 ‐0.36 (‐0.63,‐0.09) P value 0.010  
    Patient global (VAS)   ‐0.54 (‐0.81,‐0.27) P value 0.0001 ‐0.57 (‐0.84,‐0.30) P value 0.00004  
Hylan G‐F 20 + PT Physiotherapy (PT) Lequesne Index (0‐24) ‐0.24 (‐1.11,0.63) P value0.6 (end of treatment) ‐0.23 (‐1.10,0.64) P value 0.6    
Hylan G‐F 20 Appropriate care WOMAC pain (Likert)       ‐0.77 (‐1.02,‐0.51) p<0.00001
    WOMAC function (Likert)       ‐0.72 (‐0.98,‐0.45) p<0.00001
    WOMAC pain (VAS)     ‐0.60 (‐0.78,‐0.42) p<0.00001 (36 wk)  
    Pain walking (VAS)     ‐0.53 (‐0.71,‐0.36) p<0.00001 (36 wk)  
    WOMAC function (VAS)     ‐0.61 (‐0.79,‐0.43) p<0.00001 (36 wk)  
    Lequesne Index (0‐24)     ‐0.49 (‐0.67,‐0.32) p<0.00001 (36 wk)  
    WOMAC total (VAS)     ‐0.63 (‐0.81,‐0.45) p<0.00001 (36 wk)  
  Gaseous oxygen Pain under load (VAS) 0.30 (‐0.08,0.68) P value 0.12 (end of treatment) 0.44 (0.06,0.82) P value 0.02 0.27 (‐0.10,0.65) P value 0.16 0.24 (‐0.14,0.61) P value 0.2
    Pain at rest (VAS) 0.06 (‐0.32,0.43) P value 0.8 (end of treatment) 0.26 (‐0.12,0.63) P value 0.18 0.10 (‐0.28,0.48) P value 0.6 0.00 (‐0.37,0.38) P value 1
    WOMAC pain (Likert) 0.34 (‐0.04,0.71) P value 0.08 (end of treatment) 0.35 (‐0.03,0.73) P value 0.07 0.14 (‐0.24,0.51) P value 0.5 0.20 (‐0.18,0.57) P value 0.3
    WOMAC function (Likert) 0.24 (‐0.14,0.62) P value 0.2 (end of treatment) 0.21 (‐0.17,0.58) P value 0.3 0.27 (‐0.11,0.65) P value 0.16 0.26 (‐0.11,0.64) P value 0.17
    WOMAC stiffness (Likert) 0.10 (‐0.27,0.48) P value 0.6 (end of treatment) 0.28 (‐0.10,0.65) P value 0.15 0.47 (0.09,0.85) P value 0.02 0.25 (‐0.13,0.63) P value 0.2
  Hyaluronan Pain weight bearing (VAS) ‐0.08 (‐0.30,0.14) P value 0.5 ‐0.28 (‐0.64,0.09) P value 0.13 ‐0.15 (‐0.44,0.15) P value 0.3  
    Pain at night (VAS) ‐0.34 (‐0.06,‐0.01) P value 0.04 ‐0.14 (‐0.47,0.18) P value 0.4    
    Function: improvement (VAS) ‐0.02 (‐0.34,0.30) P value 0.9 0.41 (0.08,0.73) P value 0.02    
    Patient global (treatment efficacy) (VAS) 0.06 (‐0.26,0.38) P value 0.7 0.31 (‐0.02,0.63) P value 0.07    
NRD‐101 Artz Flexion (end of treatment) 0.08 (‐0.21,0.37) P value 0.6      
    Extension (end of treatment) ‐0.04 (‐0.33,0.26) P value 0.8      
Orthovisc Placebo WOMAC pain (Likert) ‐1.68 (‐2.41,‐0.95) p<0.00001 ‐1.88 (‐2.64,‐1.12) p<0.00001 ‐1.86 (‐2.61,‐1.11) p<0.00001 ‐1.87 (‐2.63,‐1.12) p<0.00001
    WOMAC function (Likert) ‐0.87 (‐1.46,‐0.17) P value 0.009 ‐0.81 (‐1.46,‐0.17) P value 0.01 ‐0.73 (‐1.38,‐0.09) P value 0.03 ‐0.52 (‐1.15,‐0.11) P value 0.11
  Betamethasone WOMAC function (VAS) 0.34 (‐0.29,0.96) P value 0.3 ‐1.06 (‐1.73,‐0.40) P value 0.002    
    Flexion (degrees) ‐0.30 (‐0.93,0.32) P value 0.3 ‐0.51 (‐1.14,0.12) P value 0.11    
  6‐MPA Pain weight bearing (VAS) 0.26 (‐0.27,0.79) P value 0.3 ‐0.92 (‐1.48,‐0.36) P value 0.001 ‐0.76 (‐1.31,‐0.21) P value 0.007  
    Pain at rest (VAS) 0.33 (‐0.21,0.86) P value 0.2 ‐0.69 (‐1.24,‐0.15) P value 0.01 ‐0.23 (‐0.76,0.30) P value 0.4  
    Pain on walking (VAS) ‐0.02 (‐0.55,0.51) P value 0.9 ‐0.89 (‐1.45,‐0.33) P value 0.002 ‐0.71 (‐1.25,‐0.16) P value 0.01  
    Lequesne Index (0‐24) ‐0.06 (‐0.59,0.46) P value 0.8 ‐0.99 (‐1.56,‐0.43) P value 0.0005 ‐0.58 (‐1.12,‐0.04) P value 0.04  
    Flexion (degrees) 0.24 (‐0.29,0.77) P value 0.4 0.29 (‐0.24,0.83) P value 0.3 0.54 (0.00,1.08) P value 0.05  
Orthovisc + PT Physiotherapy (PT) Activity pain (VAS) ‐0.19 (‐0.81,0.43) P value 0.6 ‐0.73 (‐1.37,‐0.08) P value 0.03    
    Spontaneous pain (VAS) 0.07 (‐0.55,0.69) P value 0.8 ‐0.75 (‐1.39,‐0.10) P value 0.02    
    Night pain (VAS) ‐0.03 (‐0.65,0.59) P value 0.9 ‐0.57 (‐1.20,0.07) P value 0.08    
    Lequesne Index (0‐24) ‐0.06 (‐0.87,0.76) P value 0.9 ‐0.44 (‐1.27,0.38) P value 0.3    
    25 m walk time 0.25 (‐0.37,0.87) P value 0.4 ‐0.41 (‐1.04,0.21) P value 0.19