Product |
Comparison |
Outcome |
1‐4 wk |
5‐13 wk |
14‐26 wk |
45‐52 wk |
Artz, Artzal |
Placebo |
Pain (VAS) |
0.02 (‐0.16,0.20) P value 0.8 |
‐0.19 (‐0.37,‐0.01) P value 0.04 |
0.00 (‐0.24,0.23) P value 1 |
|
|
|
Pain (0‐3) |
‐0.14 (‐0.54,0.26) P value 0.5 |
|
|
|
|
|
WOMAC pain (Likert) |
|
‐0.24 (‐0.50,0.02) P value 0.07 |
|
|
|
|
WOMAC function (Likert) |
|
‐0.22 (‐0.49,0.04) P value 0.10 |
|
|
|
|
WOMAC stiffness (Likert) |
|
‐0.24 (‐0.51,0.02) P value 0.07 |
|
|
|
|
Lequesne Index (0‐24) |
0.06 (‐0.23,0.34) P value 0.7 |
‐0.11 (‐0.39,0.17) P value 0.5 |
0.11 (‐0.09,0.31) P value 0.3 |
|
|
|
Range of motion (degrees) |
0.22 (‐0.18,0.61) P value 0.3 |
|
|
|
|
Hylan G‐F 20 |
Pain weight bearing (VAS) |
‐0.04 (‐0.34,0.26) P value 0.8 |
0.03 (‐0.26,0.33) P value 0.8 |
0.15 (‐0.15,0.44) P value 0.3 |
|
|
|
Lequesne Index (0‐24) |
|
|
0.21 (‐0.08,0.50) P value 0.16 |
|
BioHy (Arthrease) |
Hylan G‐F 20 |
WOMAC pain (VAS) |
‐0.18 (‐0.40,0.04) P value 0.10 |
‐0.19 (‐0.41,0.03) P value 0.08 |
|
|
Fermathron |
Hyalart |
Pain (VAS) |
0.11 (‐0.14,0.37) P value 0.4 |
0.04 (‐0.22,0.30) P value 0.8 |
|
|
|
|
Lequesne Index (0‐24) |
0.11 (‐0.14,0.37) P value 0.4 |
0.14 (‐0.12,0.39) P value 0.3 |
|
|
Hyalgan |
Placebo |
Pain weight bearing (VAS) |
‐0.32 (‐0.58,‐0.05) P value 0.02 |
‐0.41 (‐0.66,‐0.16) P value 0.001 |
‐0.22 (‐0.43,‐0.02) P value 0.03 |
‐0.07 (‐0.24,0.10) P value 0.4 |
|
|
Pain spontaneous (VAS) |
‐1.14 (‐1.64,‐0.64) P value 0.00001 |
‐1.07 (‐1.56,‐0.57) P value 0.00003 |
|
|
|
|
Pain at rest (VAS) |
‐0.49 (‐0.88,‐0.10) P value 0.01 |
‐0.72 (‐1.06,‐0.38) P value 0.00004 |
|
0.07 (‐0.29,0.43) P value 0.7 |
|
|
Pain at night (VAS) |
‐0.69 (‐1.88,0.50) P value 0.3 |
|
|
|
|
|
WOMAC pain (VAS) |
‐0.18 (‐0.47,0.10) P value 0.2 |
‐0.10 (‐0.40,0.19) P value 0.5 |
‐0.38 (‐0.68,‐0.08) P value 0.01 |
|
|
|
WOMAC function (VAS) |
‐0.09 (=0.37,0.20) P value 0.5 |
‐0.07 (‐0.37,0.22) P value 0.6 |
‐0.28 (‐0.57,0.02) P value 0.07 |
|
|
|
Lequesne Index (0‐24) |
‐0.39 (‐0.63,‐0.16) P value 0.0010 |
‐0.60 (‐0.89,‐0.31) P value 0.00006 |
‐0.30 (‐0.74,0.14) P value 0.18 |
‐0.28 (‐0.69,0.13) P value 0.18 |
|
|
Flexion (degrees) |
0.30 (‐0.37,0.97) P value 0.4 |
0.70 (0.01,1.39) P value 0.05 |
|
|
|
|
Synovial fluid volume (ml) |
‐0.07 (‐0.39,0.24) P value 0.6 |
‐0.51 (‐1.02,‐0.01) P value 0.04 |
|
|
|
|
Joint space width (total population) |
|
|
|
0.26 (0.02,0.49) P value 0.04 |
|
|
Joint space width (subgroups) |
|
|
|
0.12 (‐0.28,0.52) P value 0.6 |
|
Arthroscopy |
Pain (VAS) |
0.42 (‐0.31,1.15) P value 0.3 |
0.00 (‐0.70,0.70) P value 1 |
‐0.25 (‐1.00,0.49) P value 0.5 |
0.00 (‐0.79,0.79) P value 1 |
|
|
Knee Society Function Scale |
0.53 (‐0.21,1.26) P value 0.16 |
0.49 (‐0.23,1.21) P value 0.18 |
0.77 (0.00,1.54) P value 0.05 |
0.72 (‐0.10,1.54) P value 0.08 |
|
|
Lequesne Index (0‐24) |
0.53 (‐0.21,1.26) P value 0.16 |
0.49 (‐0.23,1.21) P value 0.18 |
0.77 (0.00,1.54) P value 0.05 |
0.72 (‐0.10,1.54) P value 0.08 |
|
NSAID |
Pain after 50 foot walk (VAS) |
0.00 (‐0.23,0.23) P value 1 |
0.08 (‐0.17,0.33) P value 0.5 |
‐0.13 (‐0.40,0.14) P value 0.3 |
|
|
Methylprednisolone acetate |
Spontaneous pain intensity (VAS) |
‐0.27 (‐0.58,0.03) P value 0.08 |
‐0.41 (‐0.90,0.08) P value 0.10 |
|
0.10 (‐0.60,0.79) P value 0.8 |
|
|
Range of motion (degrees) |
0.39 (0.05,0.74) P value 0.03 |
0.40 (0.05,0.75) P value 0.02 |
|
0.07 (‐0.62,0.77) P value 0.8 |
|
Triamcinolone hexacetonide |
Pain on nominated activity (VAS) |
‐0.01 (‐0.53,0.52) P value 1 (end of treatment) |
|
‐0.39 (‐1.29,0.52) P value 0.4 |
|
|
|
Pain at rest (VAS) |
‐0.02 (‐0.54,0.50) P value 0.9 (end of treatment) |
|
‐0.76 (‐1.69,0.18) P value 0.11 |
|
|
|
Pain at night (VAS) |
‐0.21 (‐0.74,0.31) P value 0.4 (end of treatment) |
|
‐1.11 (‐2.09,‐0.14) P value 0.03 |
|
|
Mucopolysaccharide polysulfuric acid ester |
Pain (0‐30) |
0.66 (0.14,1.19) P value 0.01 (end of treatment) |
|
|
|
|
|
Function (0‐30) |
0.11 (‐0.40,0.63) P value 0.7 (end of treatment) |
|
|
|
|
|
Range of motion (0‐10) |
0.39 (‐0.13,0.91) P value 0.14 (end of treatment) |
|
|
|
|
|
Total Larson rating score (0‐77) |
0.63 (0.10,1.16) P value 0.02 (end of treatment) |
|
|
|
|
Appropriate care |
Pain overall (VAS) |
|
|
|
‐0.53 (‐1.20,0.14) P value 0.12 |
|
|
Lequesne Index (0‐24) |
|
|
|
‐0.20 (‐0.85,0.46) P value 0.6 |
|
|
Joint space width (mm) |
|
|
|
0.63 (‐0.04,1.30) P value 0.07 |
|
|
Quality of life: AIMS |
|
|
|
‐0.16 (‐0.82,0.49) P value 0.6 |
|
|
Arthroscopy overall score (VAS) |
|
|
|
‐0.79 (‐1.47,‐0.10) P value 0.02 |
|
|
SFA score (VAS) |
|
|
|
‐0.90 (‐1.59,‐0.21) P value 0.01 |
Hylan G‐F 20 |
Placebo |
Pain weight bearing (VAS) |
‐0.51 (‐0.87,‐0.15) P value 0.006 |
‐0.94 (‐1.57,‐0.31) P value 0.003 |
‐0.77 (‐1.38,‐0.15) P value 0.01 |
|
|
|
Pain at night (VAS) |
‐0.30 (‐0.50,‐0.09) P value 0.005 |
‐0.52 (‐1.00,‐0.05) P value 0.03 |
‐0.82 (‐1.12,‐0.51) p<0.00001 |
|
|
|
WOMAC pain (VAS) |
|
‐0.31 (‐0.68,0.07) P value 0.11 |
|
|
|
|
Pain at rest (VAS) |
‐0.14 (‐0.55,0.26) P value 0.5 |
|
|
|
|
|
Pain overall (VAS) |
‐0.07 (‐0.48,0.33) P value 0.7 |
|
|
|
|
|
Lequesne Index (0‐24) |
|
|
0.02 (‐0.30,0.34) P value 0.9 |
|
|
|
WOMAC function (VAS) |
|
‐0.43 (‐0.81,‐0.05) P value 0.03 |
|
|
|
|
Function: improvement (VAS) |
0.63 (0.39,0.88) p<0.00001 |
1.29 (0.97,1.60) p<0.00001 |
|
|
|
|
Patient global: treatment efficacy (VAS) |
0.72 (0.47,0.96) p<0.00001 |
1.19 (0.66,1.71) P value 0.00001 |
|
|
|
NSAID |
Pain on motion (VAS) |
|
‐0.27 (‐0.80,0.25) P value 0.3 |
‐0.49 (‐1.02,0.03) P value 0.07 |
|
|
|
Pain at rest (VAS) |
|
‐0.14 (‐0.66,0.39) P value 0.6 |
‐0.15 (‐0.67,0.36) P value 0.6 |
|
|
|
Pain at night (VAS) |
|
‐0.29 (‐0.82,0.23) P value 0.3 |
‐0.12 (‐0.64,0.39) P value 0.6 |
|
|
|
Pain overall (VAS) |
|
‐0.18 (‐0.71,0.34) P value 0.5 |
‐0.23 (‐0.75,0.29) P value 0.4 |
|
|
|
WOMAC pain (VAS) |
|
‐0.41 (‐0.79,‐0.02) P value 0.04 |
|
|
|
|
WOMAC function (VAS) |
|
‐0.21 (‐0.59,0.16) P value 0.3 |
|
|
|
|
Lequesne Index (0‐24) |
|
‐0.27 (‐0.65,0.11) P value 0.16 |
|
|
Hylan G‐F 20 + NSAID |
NSAID |
Pain on motion (VAS) |
|
‐0.44 (‐0.93,0.06) P value 0.08 |
‐0.66 (‐1.17,‐0.15) P value 0.01 |
|
|
|
Pain at rest (VAS) |
|
‐0.44 (‐0.93,0.06) P value 0.08 |
‐0.66 (‐1.17,‐0.15) P value 0.01 |
|
|
|
Pain at night (VAS) |
|
‐0.48 (‐0.98,0.02) P value 0.06 |
‐0.84 (‐1.35,‐0.32) P value 0.002 |
|
|
|
Pain overall (VAS) |
|
‐0.46 (‐0.96,0.03) P value 0.07 |
‐0.66 (‐1.17,‐0.15) P value 0.01 |
|
Hylan G‐F 20 |
Triamcinolone hexacetonide |
WOMAC pain Q1 (Likert) |
|
‐0.43 (‐0.70,‐0.16) P value 0.002 |
‐0.38 (‐0.65,‐0.11) P value 0.005 |
|
|
|
WOMAC function (Likert) |
|
‐0.35 (‐0.62,‐0.08) P value 0.01 |
‐0.36 (‐0.63,‐0.09) P value 0.010 |
|
|
|
WOMAC total score (Likert) |
|
‐0.37 (‐0.64,‐0.10) P value 0.007 |
‐0.36 (‐0.63,‐0.09) P value 0.010 |
|
|
|
Patient global (VAS) |
|
‐0.54 (‐0.81,‐0.27) P value 0.0001 |
‐0.57 (‐0.84,‐0.30) P value 0.00004 |
|
Hylan G‐F 20 + PT |
Physiotherapy (PT) |
Lequesne Index (0‐24) |
‐0.24 (‐1.11,0.63) P value0.6 (end of treatment) |
‐0.23 (‐1.10,0.64) P value 0.6 |
|
|
Hylan G‐F 20 |
Appropriate care |
WOMAC pain (Likert) |
|
|
|
‐0.77 (‐1.02,‐0.51) p<0.00001 |
|
|
WOMAC function (Likert) |
|
|
|
‐0.72 (‐0.98,‐0.45) p<0.00001 |
|
|
WOMAC pain (VAS) |
|
|
‐0.60 (‐0.78,‐0.42) p<0.00001 (36 wk) |
|
|
|
Pain walking (VAS) |
|
|
‐0.53 (‐0.71,‐0.36) p<0.00001 (36 wk) |
|
|
|
WOMAC function (VAS) |
|
|
‐0.61 (‐0.79,‐0.43) p<0.00001 (36 wk) |
|
|
|
Lequesne Index (0‐24) |
|
|
‐0.49 (‐0.67,‐0.32) p<0.00001 (36 wk) |
|
|
|
WOMAC total (VAS) |
|
|
‐0.63 (‐0.81,‐0.45) p<0.00001 (36 wk) |
|
|
Gaseous oxygen |
Pain under load (VAS) |
0.30 (‐0.08,0.68) P value 0.12 (end of treatment) |
0.44 (0.06,0.82) P value 0.02 |
0.27 (‐0.10,0.65) P value 0.16 |
0.24 (‐0.14,0.61) P value 0.2 |
|
|
Pain at rest (VAS) |
0.06 (‐0.32,0.43) P value 0.8 (end of treatment) |
0.26 (‐0.12,0.63) P value 0.18 |
0.10 (‐0.28,0.48) P value 0.6 |
0.00 (‐0.37,0.38) P value 1 |
|
|
WOMAC pain (Likert) |
0.34 (‐0.04,0.71) P value 0.08 (end of treatment) |
0.35 (‐0.03,0.73) P value 0.07 |
0.14 (‐0.24,0.51) P value 0.5 |
0.20 (‐0.18,0.57) P value 0.3 |
|
|
WOMAC function (Likert) |
0.24 (‐0.14,0.62) P value 0.2 (end of treatment) |
0.21 (‐0.17,0.58) P value 0.3 |
0.27 (‐0.11,0.65) P value 0.16 |
0.26 (‐0.11,0.64) P value 0.17 |
|
|
WOMAC stiffness (Likert) |
0.10 (‐0.27,0.48) P value 0.6 (end of treatment) |
0.28 (‐0.10,0.65) P value 0.15 |
0.47 (0.09,0.85) P value 0.02 |
0.25 (‐0.13,0.63) P value 0.2 |
|
Hyaluronan |
Pain weight bearing (VAS) |
‐0.08 (‐0.30,0.14) P value 0.5 |
‐0.28 (‐0.64,0.09) P value 0.13 |
‐0.15 (‐0.44,0.15) P value 0.3 |
|
|
|
Pain at night (VAS) |
‐0.34 (‐0.06,‐0.01) P value 0.04 |
‐0.14 (‐0.47,0.18) P value 0.4 |
|
|
|
|
Function: improvement (VAS) |
‐0.02 (‐0.34,0.30) P value 0.9 |
0.41 (0.08,0.73) P value 0.02 |
|
|
|
|
Patient global (treatment efficacy) (VAS) |
0.06 (‐0.26,0.38) P value 0.7 |
0.31 (‐0.02,0.63) P value 0.07 |
|
|
NRD‐101 |
Artz |
Flexion (end of treatment) |
0.08 (‐0.21,0.37) P value 0.6 |
|
|
|
|
|
Extension (end of treatment) |
‐0.04 (‐0.33,0.26) P value 0.8 |
|
|
|
Orthovisc |
Placebo |
WOMAC pain (Likert) |
‐1.68 (‐2.41,‐0.95) p<0.00001 |
‐1.88 (‐2.64,‐1.12) p<0.00001 |
‐1.86 (‐2.61,‐1.11) p<0.00001 |
‐1.87 (‐2.63,‐1.12) p<0.00001 |
|
|
WOMAC function (Likert) |
‐0.87 (‐1.46,‐0.17) P value 0.009 |
‐0.81 (‐1.46,‐0.17) P value 0.01 |
‐0.73 (‐1.38,‐0.09) P value 0.03 |
‐0.52 (‐1.15,‐0.11) P value 0.11 |
|
Betamethasone |
WOMAC function (VAS) |
0.34 (‐0.29,0.96) P value 0.3 |
‐1.06 (‐1.73,‐0.40) P value 0.002 |
|
|
|
|
Flexion (degrees) |
‐0.30 (‐0.93,0.32) P value 0.3 |
‐0.51 (‐1.14,0.12) P value 0.11 |
|
|
|
6‐MPA |
Pain weight bearing (VAS) |
0.26 (‐0.27,0.79) P value 0.3 |
‐0.92 (‐1.48,‐0.36) P value 0.001 |
‐0.76 (‐1.31,‐0.21) P value 0.007 |
|
|
|
Pain at rest (VAS) |
0.33 (‐0.21,0.86) P value 0.2 |
‐0.69 (‐1.24,‐0.15) P value 0.01 |
‐0.23 (‐0.76,0.30) P value 0.4 |
|
|
|
Pain on walking (VAS) |
‐0.02 (‐0.55,0.51) P value 0.9 |
‐0.89 (‐1.45,‐0.33) P value 0.002 |
‐0.71 (‐1.25,‐0.16) P value 0.01 |
|
|
|
Lequesne Index (0‐24) |
‐0.06 (‐0.59,0.46) P value 0.8 |
‐0.99 (‐1.56,‐0.43) P value 0.0005 |
‐0.58 (‐1.12,‐0.04) P value 0.04 |
|
|
|
Flexion (degrees) |
0.24 (‐0.29,0.77) P value 0.4 |
0.29 (‐0.24,0.83) P value 0.3 |
0.54 (0.00,1.08) P value 0.05 |
|
Orthovisc + PT |
Physiotherapy (PT) |
Activity pain (VAS) |
‐0.19 (‐0.81,0.43) P value 0.6 |
‐0.73 (‐1.37,‐0.08) P value 0.03 |
|
|
|
|
Spontaneous pain (VAS) |
0.07 (‐0.55,0.69) P value 0.8 |
‐0.75 (‐1.39,‐0.10) P value 0.02 |
|
|
|
|
Night pain (VAS) |
‐0.03 (‐0.65,0.59) P value 0.9 |
‐0.57 (‐1.20,0.07) P value 0.08 |
|
|
|
|
Lequesne Index (0‐24) |
‐0.06 (‐0.87,0.76) P value 0.9 |
‐0.44 (‐1.27,0.38) P value 0.3 |
|
|
|
|
25 m walk time |
0.25 (‐0.37,0.87) P value 0.4 |
‐0.41 (‐1.04,0.21) P value 0.19 |
|
|