| Product |
Comparison |
Outcome |
1‐4 wk |
5‐13 wk |
14‐26 wk |
45‐52 wk |
| Orthovisc+PT |
Hylan G‐F 20+PT |
Lequesne Index (0‐24) |
0.16 (‐0.59,0.91) P value 0.7 (End of treatment) |
‐0.30 (‐1.05,0.45) P value 0.4 |
|
|
| Suplasyn |
Placebo |
Pain after walking (VAS) |
‐0.38 (‐0.92,0.17) P value 0.17 |
|
|
|
| |
|
WOMAC pain (VAS) |
‐0.29 (‐0.83,0.25) P value 0.3 |
|
|
|
| |
|
Pain at rest (VAS) |
0.56 (0.01,1.11) P value 0.05 |
|
|
|
| |
|
WOMAC function (VAS) |
‐0.47 (‐1.02,0.07) P value 0.09 |
|
|
|
| |
|
Walk time (sec) |
0.18 (‐0.36,0.72) P value 0.5 |
|
|
|
| |
NSAID |
Pain after walking (VAS) |
0.39 (‐0.15,0.93) P value 0.16 |
|
|
|
| |
|
WOMAC pain (VAS) |
‐0.17 (‐0.70,0.37) P value 0.5 |
|
|
|
| |
|
Pain at rest (VAS) |
0.40 (‐0.14,0.95) P value 0.14 |
|
|
|
| |
|
WOMAC function (VAS) |
‐0.13 (‐0.66,0.41) P value 0.6 |
|
|
|
| |
|
Walk time (sec) |
‐0.09 (‐0.62,0.45) P value 0.7 |
|
|
|
| Suplasyn+NSAID |
NSAID |
Pain after walking (VAS) |
0.09 (‐0.44,0.62) P value 0.7 |
|
|
|
| |
|
WOMAC pain (VAS) |
‐0.10 (‐0.63,0.43) P value 0.7 |
|
|
|
| |
|
Pain at rest (VAS) |
‐0.01 (‐0.54,0.52) P value 1 |
|
|
|
| |
|
WOMAC function (VAS) |
‐0.01 (‐0.54,0.52) P value 1 |
|
|
|
| |
|
Walk time (sec) |
‐0.21 (‐0.74,0.32) P value 0.4 |
|
|
|
| Zeel |
Hyalart |
Pain during movement (VAS) |
0.23 (‐0.15,0.61) P value 0.2 (end of treatment) |
|
|
|
| |
|
Pain during night (VAS) |
0.09 (‐0.29,0.47) P value 0.6 (end of treatment) |
|
|
|
| |
|
Patient assessment of improvement (VAS) |
‐0.16 (‐0.53,0.21) P value 0.4 (end of treatment) |
|
|
|
| |
|
Patient assessment of tolerance (VAS) |
‐0.16 (‐0.53,0.21) P value 0.4 (end of treatment) |
|
|
|
| HA/Hylan (Pooled) |
Placebo |
Pain weight bearing (VAS) |
‐0.37 (‐0.55,‐0.19) P < 0.0001 |
‐0.33 (‐0.55,‐0.11) P value 0.004 |
‐0.33 (‐0.55,‐0.11) P value 0.004 |
‐0.09 (‐0.27,0.08) P value 0.3 |
| |
|
Pain at rest (VAS) |
‐0.27 (‐0.65,0.11) P value 0.17 |
|
|
|
| |
|
WOMAC pain (VAS) |
‐0.21 (‐0.46,0.05) P value 0.11 |
‐0.23 (‐0.46,0.00) P value 0.05 |
‐0.38 (‐0.68,‐0.08) P value 0.01 |
|
| |
|
WOMAC function (VAS) |
‐0.17 (‐0.42,0.08) P value 0.19 |
‐0.75 (‐1.12,‐0.38) P value 0.00008 |
|
|
| |
|
Lequesne Index (0‐24) |
‐0.21 (‐0.39,‐0.03) P value 0.02 |
‐0.36 (‐0.54,‐0.18) P < 0.0001 |
0.01 (‐0.16,0.19) P value 0.9 |
‐0.28 (‐0.69,0.13) P value 0.18 |
| |
|
Flexion (degrees) |
0.24 (‐0.10,0.58) P value 0.17 |
0.70 (0.01,1.39) P value 0.05 |
|
|
