Comparison 1. Adant versus Hyalgan.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Patient global assessment (number of patients excellent/good)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 1 to 4 weeks post‐injection	1	49	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [0.57, 2.41]
1.2 5 to 13 weeks post‐injection	1	49	Risk Ratio (M‐H, Fixed, 95% CI)	2.38 [0.93, 6.09]
1.3 14 to 26 weeks post‐injection	1	49	Risk Ratio (M‐H, Fixed, 95% CI)	2.11 [0.67, 6.70]
2 Safety: number of painful injections	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 1 to 4 weeks post‐injection	1	49	Risk Ratio (M‐H, Fixed, 95% CI)	1.9 [0.43, 8.46]