Comparison 4. BioHy (Arthrease, Euflexxa) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Safety: total withdrawals overall	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 14 to 26 weeks post‐injection	1	49	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.18, 2.89]
2 Safety: number of adverse events for injection site pain	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 14 to 26 weeks post‐injection	1	49	Risk Ratio (M‐H, Fixed, 95% CI)	1.57 [0.95, 2.59]