Comparison 9. Hyalgan versus arthroscopy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain (0‐10 cm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 Pre‐trial	1	33	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐1.39, 1.59]
1.2 1 week post‐injection	1	30	Mean Difference (IV, Fixed, 95% CI)	1.20 [‐0.88, 3.28]
1.3 5 to 12 weeks post‐injection	1	31	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐2.51, 2.51]
1.4 14 to 26 weeks post‐injection	1	28	Mean Difference (IV, Fixed, 95% CI)	‐0.90 [‐3.46, 1.66]
1.5 45 to 52 weeks post‐injection	1	25	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐2.47, 2.47]
2 Knee Society Function scale	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 Pre‐trial	1	33	Mean Difference (IV, Fixed, 95% CI)	22.40 [6.27, 38.53]
2.2 1 week post‐injection	1	30	Mean Difference (IV, Fixed, 95% CI)	16.9 [‐6.32, 40.12]
2.3 5 to 13 weeks post‐injection	1	31	Mean Difference (IV, Fixed, 95% CI)	16.20 [‐6.50, 38.90]
2.4 14 to 26 weeks post‐injection	1	28	Mean Difference (IV, Fixed, 95% CI)	23.5 [1.68, 45.32]
2.5 45 to 52 weeks post ‐injection	1	25	Mean Difference (IV, Fixed, 95% CI)	23.9 [‐1.45, 49.25]
3 Lequesne Index (0‐24)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 Pre‐trial	1	33	Mean Difference (IV, Fixed, 95% CI)	‐1.90 [‐4.84, 1.04]
3.2 1 week post‐injection	1	30	Mean Difference (IV, Fixed, 95% CI)	0.60 [‐3.72, 4.92]
3.3 5 to 13 weeks post‐injection	1	31	Mean Difference (IV, Fixed, 95% CI)	‐0.60 [‐5.00, 3.80]
3.4 14 to 26 weeks post‐injection	1	28	Mean Difference (IV, Fixed, 95% CI)	‐3.0 [‐7.58, 1.58]
3.5 45 to 52 weeks post‐injection	1	25	Mean Difference (IV, Fixed, 95% CI)	‐2.90 [‐8.10, 2.30]
4 Clinical outcome (number of patients requiring further intervention)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 45 to 52 weeks post‐injection	1	32	Risk Ratio (M‐H, Fixed, 95% CI)	2.06 [0.64, 6.57]
5 Safety: total withdrawals overall	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 45 to 52 weeks post‐injection	1	38	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.10, 2.41]
6 Safety: number of patients with pain at injection site	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only