Comparison 15. (Hyalgan plus exercise plus ultrasound) versus exercise.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain (0‐10 cm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 End of treatment	1	64	Mean Difference (IV, Fixed, 95% CI)	‐1.60 [‐2.18, ‐1.02]
1.2 One‐year follow‐up	1	58	Mean Difference (IV, Fixed, 95% CI)	‐1.9 [‐2.60, ‐1.20]
2 Lequesne Index (0‐26)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 End of treatment	1	64	Mean Difference (IV, Fixed, 95% CI)	‐2.10 [‐2.50, ‐1.70]
2.2 One‐year follow‐up	1	58	Mean Difference (IV, Fixed, 95% CI)	‐3.30 [‐4.19, ‐2.41]
3 Range of motion (degrees)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 End of treatment	1	64	Mean Difference (IV, Fixed, 95% CI)	12.0 [4.51, 19.49]
3.2 One‐year follow‐up	1	58	Mean Difference (IV, Fixed, 95% CI)	14.0 [5.76, 22.24]
4 Ambulation speed (metres per minute)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 End of treatment	1	64	Mean Difference (IV, Fixed, 95% CI)	12.70 [10.60, 14.80]
4.2 One‐year follow‐up	1	58	Mean Difference (IV, Fixed, 95% CI)	14.0 [10.57, 17.43]
5 Safety: total withdrawals overall	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 During treatment	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	0.2 [0.02, 1.63]
5.2 Overall	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.10, 1.13]