Comparison 16. (Hyalgan plus exercise plus ultrasound) versus (exercise plus ultrasound).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain (0‐10 cm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 End of treatment	1	66	Mean Difference (IV, Fixed, 95% CI)	‐0.5 [‐1.32, 0.32]
1.2 One‐year follow‐up	1	61	Mean Difference (IV, Fixed, 95% CI)	‐0.60 [‐1.31, 0.11]
2 Lequesne Index (0‐26)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 End of treatment	1	66	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐0.85, 0.05]
2.2 One‐year follow‐up	1	61	Mean Difference (IV, Fixed, 95% CI)	‐0.80 [‐1.58, ‐0.02]
3 Range of motion (degrees)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 End of treatment	1	66	Mean Difference (IV, Fixed, 95% CI)	6.0 [‐0.79, 12.79]
3.2 One‐year follow‐up	1	61	Mean Difference (IV, Fixed, 95% CI)	6.00 [‐2.05, 14.05]
4 Ambulation speed (metres per minute)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 End of treatment	1	66	Mean Difference (IV, Fixed, 95% CI)	5.40 [3.99, 6.81]
4.2 One‐year follow‐up	1	61	Mean Difference (IV, Fixed, 95% CI)	5.0 [1.58, 8.42]
5 Safety: total withdrawals overall	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 During treatment	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.04, 3.05]
5.2 Overall	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.14, 1.84]