Comparison 22. (Hylan G‐F 20 + NSAID + arthrocentesis) versus (NSAID + arthrocentesis).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain on motion (0‐100 mm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 5 to 13 weeks post‐injection	1	64	Mean Difference (IV, Fixed, 95% CI)	‐10.0 [‐21.09, 1.09]
1.2 14 to 26 weeks post‐injection	1	63	Mean Difference (IV, Fixed, 95% CI)	‐15.0 [‐26.09, ‐3.91]
2 Pain at rest (0‐100 mm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 5 to 13 weeks post‐injection	1	64	Mean Difference (IV, Fixed, 95% CI)	‐6.00 [‐17.09, 5.09]
2.2 14 to 26 weeks post‐injection	1	63	Mean Difference (IV, Fixed, 95% CI)	‐11.0 [‐19.31, ‐2.69]
3 Pain at night (0‐100 mm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 5 to 13 weeks post‐injection	1	64	Mean Difference (IV, Fixed, 95% CI)	‐11.0 [‐22.09, 0.09]
3.2 14 to 26 weeks post‐injection	1	63	Mean Difference (IV, Fixed, 95% CI)	‐19.0 [‐30.09, ‐7.91]
4 Pain overall (0‐100 mm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 5 to 13 weeks post‐injection	1	64	Mean Difference (IV, Fixed, 95% CI)	‐10.00 [‐24.55, 0.55]
4.2 14 to 26 weeks post‐injection	1	63	Mean Difference (IV, Fixed, 95% CI)	‐15.0 [‐26.09, ‐3.91]
5 Patient overall assessment of treatment (number of patients excellent, very good, or good)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 14 to 26 weeks post‐injection	1	59	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.73, 1.70]
6 Safety: total withdrawals overall	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 14 to 26 weeks post‐injection	1	71	Risk Ratio (M‐H, Fixed, 95% CI)	1.53 [0.40, 5.93]