| 1 WOMAC pain walking on a flat surface (Question 1: 0‐4 Likert) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.1 5 to 13 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.40 [‐0.65, ‐0.15] |
| 1.2 14 to 26 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.40 [‐0.68, ‐0.12] |
| 2 WOMAC physical function subscale (0‐68 Likert) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 2.1 5 to 13 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.0 [‐8.86, ‐1.14] |
| 2.2 14 to 26 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.20 [‐9.10, ‐1.30] |
| 3 WOMAC total score (0‐96 Likert) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 3.1 5 to 13 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐7.40 [‐12.74, ‐2.06] |
| 3.2 14 to 26 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐7.30 [‐12.76, ‐1.84] |
| 4 Patient global overall assessment (0‐100 mm VAS) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 4.1 5 to 13 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐13.40 [‐20.03, ‐6.77] |
| 4.2 14 to 26 weeks post‐injection |
1 |
215 |
Mean Difference (IV, Fixed, 95% CI) |
‐15.10 [‐22.17, ‐8.03] |
| 5 Number of responders (greater than or equal to one category on WOMAC pain Q1) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 5.1 1 to 4 weeks post‐injection |
1 |
215 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.21 [0.96, 1.53] |
| 5.2 5 to 13 weeks post‐injection |
1 |
215 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.44 [1.09, 1.90] |
| 5.3 14 to 26 weeks post‐injection |
1 |
215 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.44 [1.00, 2.09] |
| 6 Analgesic usage |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 6.1 From week 0 to prior to week 12 |
1 |
215 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.01 [0.97, 1.06] |
| 6.2 From week 12 prior to week 26 |
1 |
153 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.84 [0.64, 1.11] |
| 7 Safety: total withdrawals overall |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 8 Safety: withdrawals due to adverse event |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 9 Safety: withdrawals due to lack of efficacy |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
