Comparison 25. Hylan G‐F 20 versus physical therapy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Spontaneous pain (0‐100 mm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	20.5 [10.21, 30.79]
1.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐4.0 [‐14.48, 6.48]
1.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	2.20 [‐8.23, 12.63]
1.4 37 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	1.0 [‐9.15, 11.15]
1.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐10.5 [‐21.47, 0.47]
2 WOMAC pain	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐3.0 [‐4.85, ‐1.15]
2.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐3.10 [‐5.12, ‐1.08]
2.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.90 [‐3.33, 1.53]
2.4 37 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐1.90 [‐3.71, ‐0.09]
2.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐5.30 [‐7.50, ‐3.10]
3 WOMAC physical function	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	2.5 [‐6.35, 11.35]
3.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	2.80 [‐5.75, 11.35]
3.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐9.30, 9.30]
3.4 37 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.40 [‐6.88, 7.68]
3.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.70 [‐6.84, 8.24]
4 SF‐36 pain	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.30 [‐11.18, 11.78]
4.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	2.60 [‐9.69, 14.89]
4.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	1.10 [‐13.22, 15.42]
4.4 37 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐7.5 [‐17.09, 2.09]
4.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐3.5 [‐15.18, 8.18]
5 SF‐36 physical functioning	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	3.5 [‐12.00, 19.00]
5.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	8.20 [‐4.48, 20.88]
5.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	1.70 [‐13.64, 17.04]
5.4 37 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐4.20 [‐17.28, 8.88]
5.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	1.0 [‐14.09, 16.09]