Comparison 27. Hylan G‐F 20 versus progressive knee exercises.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain during activity	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 1 to 4 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	1.90 [0.19, 3.61]
1.2 5 to 13 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	1.70 [0.17, 3.23]
1.3 14 to 26 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	2.5 [0.85, 4.15]
1.4 45 to 52 weeks post‐injection	1	99	Mean Difference (IV, Fixed, 95% CI)	‐1.70 [‐3.42, 0.02]
1.5 74 weeks post‐injection	1	84	Mean Difference (IV, Fixed, 95% CI)	0.80 [‐0.66, 2.26]
2 Pain at rest	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 1 to 4 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.90 [‐0.45, 2.25]
2.2 5 to 13 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐1.24, 1.24]
2.3 14 to 26 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.40 [‐0.96, 1.76]
2.4 45 to 52 weeks post‐injection	1	99	Mean Difference (IV, Fixed, 95% CI)	‐1.20 [‐2.61, 0.21]
2.5 74 weeks post‐injection	1	84	Mean Difference (IV, Fixed, 95% CI)	0.5 [‐0.69, 1.69]
3 Pain during climbing stairs	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 1 to 4 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.20 [‐0.34, 0.74]
3.2 5 to 13 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐0.44, 0.64]
3.3 14 to 26 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐0.54, 0.54]
3.4 45 to 52 weeks post‐injection	1	99	Mean Difference (IV, Fixed, 95% CI)	‐0.10 [‐0.65, 0.45]
3.5 74 weeks post‐injection	1	84	Mean Difference (IV, Fixed, 95% CI)	0.20 [‐0.42, 0.82]
4 Pain during transfer activity	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 1 to 4 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐0.80, 0.20]
4.2 5 to 13 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐0.66, 0.26]
4.3 14 to 26 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐0.46, 0.46]
4.4 45 to 52 weeks post‐injection	1	99	Mean Difference (IV, Fixed, 95% CI)	‐0.5 [‐0.95, ‐0.05]
4.5 74 weeks post‐injection	1	84	Mean Difference (IV, Fixed, 95% CI)	‐0.10 [‐0.68, 0.48]
5 Walking distance	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 1 to 4 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.90 [0.01, 1.79]
5.2 5 to 13 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.40 [‐0.34, 1.14]
5.3 14 to 26 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.70 [‐0.21, 1.61]
5.4 45 to 52 weeks post‐injection	1	99	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐1.31, 0.71]
5.5 74 weeks post‐injection	1	84	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐1.04, 1.24]
6 Range of motion (degrees)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6.1 1 to 4 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	‐0.80 [‐5.03, 3.43]
6.2 5 to 13 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	‐0.80 [‐4.84, 3.24]
6.3 14 to 26 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐3.84, 3.84]
6.4 45 to 52 weeks post‐injection	1	99	Mean Difference (IV, Fixed, 95% CI)	‐0.60 [‐4.57, 3.37]
6.5 74 weeks post‐injection	1	84	Mean Difference (IV, Fixed, 95% CI)	0.70 [‐4.05, 5.45]
7 Hospital for Special Surgery Knee Score (100 points)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
7.1 1 to 4 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	1.50 [‐3.09, 6.09]
7.2 5 to 13 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	0.68 [‐3.50, 4.86]
7.3 14 to 26 weeks post‐injection	1	105	Mean Difference (IV, Fixed, 95% CI)	2.70 [‐1.78, 7.18]
7.4 45 to 52 weeks post‐injection	1	99	Mean Difference (IV, Fixed, 95% CI)	‐3.96 [‐8.95, 1.03]
7.5 74 weeks post‐injection	1	84	Mean Difference (IV, Fixed, 95% CI)	0.5 [‐4.11, 5.11]
8 Safety: total withdrawals overall	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only