Comparison 37. Orthovisc versus (Orthovisc plus triamcinolone acetonide).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain (0‐100 mm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	13.0 [3.77, 22.23]
1.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐2.0 [‐11.36, 7.36]
1.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	5.0 [‐3.99, 13.99]
1.4 34 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	2.0 [‐8.62, 12.62]
1.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.60 [‐11.61, 10.41]
2 WOMAC pain (0‐20 Likert)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.80 [‐1.64, 3.24]
2.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐1.10 [‐3.54, 1.34]
2.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐1.20 [‐4.13, 1.73]
2.4 34 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.10 [‐2.99, 2.79]
2.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐3.03, 3.23]
3 WOMAC physical function (0‐68 Likert)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	5.0 [‐3.41, 13.41]
3.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	6.80 [‐0.62, 14.22]
3.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	5.30 [‐1.98, 12.58]
3.4 34 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	4.30 [‐1.73, 10.33]
3.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	3.10 [‐4.32, 10.52]
4 50 foot walking time (seconds)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐3.06, 3.26]
4.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.20 [‐3.16, 3.56]
4.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐3.32, 2.92]
4.4 34 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐1.0 [‐2.95, 0.95]
4.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐3.50, 3.10]
5 Range of motion (degrees)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐3.0 [‐10.55, 4.55]
5.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐4.90 [‐12.00, 2.20]
5.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐4.20 [‐11.66, 3.26]
5.4 34 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐4.30 [‐12.53, 3.93]
5.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	‐4.5 [‐12.50, 3.50]
6 WOMAC stiffness (0‐8 Likert)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.80 [0.02, 1.58]
6.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.20 [‐0.59, 0.99]
6.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.40 [‐0.23, 1.03]
6.4 34 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.80 [0.12, 1.48]
6.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	0.80 [0.06, 1.54]
7 WOMAC total score (0‐96 Likert)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
7.1 1 to 4 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	6.80 [‐3.31, 16.91]
7.2 5 to 13 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	5.90 [‐3.58, 15.38]
7.3 14 to 26 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	4.5 [‐4.84, 13.84]
7.4 34 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	4.90 [‐2.99, 12.79]
7.5 45 to 52 weeks post‐injection	1	40	Mean Difference (IV, Fixed, 95% CI)	3.90 [‐5.24, 13.04]
8 Safety: total withdrawals overall	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
9 Safety: withdrawals due to lack of efficacy	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
10 Safety: number of patients reporting adverse events (local reactions)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only