1 WOMAC pain (0‐20 or 5‐25 Likert) |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
1.1 1 to 4 weeks post‐injection |
3 |
121 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.07 [‐0.29, 0.43] |
1.2 5 to 13 weeks post‐injection |
2 |
81 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.28 [‐0.16, 0.73] |
1.3 14 to 26 weeks post‐injection |
2 |
81 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.14 [‐0.29, 0.58] |
1.4 37 weeks post‐injection |
1 |
40 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐0.62, 0.62] |
1.5 45 to 52 weeks post‐injection |
1 |
40 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.30 [‐0.32, 0.93] |
2 Spontaneous pain (0‐100 mm VAS) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
2.1 1 to 4 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐21.1 [‐33.08, ‐9.12] |
2.2 5 to 13 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
12.90 [0.85, 24.95] |
2.3 14 to 26 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
15.5 [0.80, 30.20] |
2.4 37 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
0.5 [‐11.67, 12.67] |
2.5 45 to 52 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
7.70 [‐3.94, 19.34] |
3 SF‐36 pain |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
3.1 1 to 4 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐11.90 [‐25.49, 1.69] |
3.2 5 to 13 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐30.80 [‐43.03, ‐18.57] |
3.3 14 to 26 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐19.80 [‐35.52, ‐4.08] |
3.4 37 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
1.5 [‐7.67, 10.67] |
3.5 45 to 52 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐9.0 [‐21.67, 3.67] |
4 Hospital for Special Surgery Knee Score |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
4.1 1 to 4 weeks post‐injection |
1 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐4.04, 3.64] |
4.2 5 to 13 weeks post‐injection |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
1.0 [‐3.04, 5.04] |
4.3 14 to 26 weeks post‐injection |
1 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.0 [‐5.65, 3.65] |
4.4 45 to 52 weeks post‐injection |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐5.99, 5.79] |
5 Pain during activity (Hospital for Special Surgery) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
5.1 1 to 4 weeks post‐injection |
1 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐1.71, 1.71] |
5.2 5 to 13 weeks post‐injection |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
1.0 [‐0.79, 2.79] |
5.3 14 to 26 weeks post‐injection |
1 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐2.08, 1.88] |
5.4 45 to 52 weeks post‐injection |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.30 [‐2.89, 2.29] |
6 Pain at rest (Hospital for Special Surgery) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
6.1 1 to 4 weeks post‐injection |
1 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
1.10 [0.01, 2.19] |
6.2 5 to 13 weeks post‐injection |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
0.20 [‐1.15, 1.55] |
6.3 14 to 26 weeks post‐injection |
1 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.30 [‐1.75, 1.15] |
6.4 45 to 52 weeks post‐injection |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
0.30 [‐1.48, 2.08] |
7 Pain during climbing stairs (Hospital for Special Surgery) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
7.1 1 to 4 weeks post‐injection |
1 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐0.66, 0.66] |
7.2 5 to 13 weeks post‐injection |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.79, 0.59] |
7.3 14 to 26 weeks post‐injection |
1 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.75, 0.55] |
7.4 45 to 52 weeks post‐injection |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.40 [‐1.10, 0.30] |
8 Pain during transfer activity (Hospital for Special Surgery) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
8.1 1 to 4 weeks post‐injection |
1 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.20 [‐0.80, 0.40] |
8.2 5 to 13 weeks post‐injection |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
0.40 [‐0.16, 0.96] |
8.3 14 to 26 weeks post‐injection |
1 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
0.10 [‐0.55, 0.75] |
8.4 45 to 52 weeks post‐injection |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
0.20 [‐0.47, 0.87] |
9 WOMAC physical function (0‐68 or 17‐85 Likert) |
3 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
9.1 1 to 4 weeks post‐injection |
3 |
121 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.07 [‐0.29, 0.43] |
9.2 5 to 13 weeks post‐injection |
2 |
81 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.13 [‐0.57, 0.31] |
9.3 14 to 26 weeks post‐injection |
2 |
81 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.16 [‐0.28, 0.60] |
9.4 37 weeks post‐injection |
1 |
40 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.08 [‐0.54, 0.70] |
9.5 45 to 52 weeks post‐injection |
1 |
40 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.72, 0.52] |
10 SF‐36 physical functioning |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
10.1 1 to 4 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.00 [‐16.53, 10.53] |
10.2 5 to 13 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐20.20 [‐29.47, ‐10.93] |
10.3 14 to 26 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐11.20 [‐27.49, 5.09] |
10.4 37 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
4.20 [‐7.51, 15.91] |
10.5 45 to 52 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐21.00 [‐35.97, ‐10.03] |
11 Range of motion (degrees) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
11.1 1 to 4 weeks post‐injection |
1 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
2.40 [‐2.69, 7.49] |
11.2 5 to 13 weeks post‐injection |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
0.90 [‐2.87, 4.67] |
11.3 14 to 26 weeks post‐injection |
1 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.80 [‐6.48, 2.88] |
11.4 45 to 52 weeks post‐injection |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
0.70 [‐4.52, 5.92] |
12 Walking distance |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
12.1 1 to 4 weeks post‐injection |
1 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.20 [‐2.49, 0.09] |
12.2 5 to 13 weeks post‐injection |
1 |
73 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.90 [‐2.11, 0.31] |
12.3 14 to 26 weeks post‐injection |
1 |
71 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.90 [‐2.07, 0.27] |
12.4 45 to 52 weeks post‐injection |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.60 [‐1.92, 0.72] |
13 Patient global assessment (0‐100 mm VAS where 100 is worst severity) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
13.1 1 to 4 weeks post‐injection |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐8.27, 8.27] |
13.2 5 to 13 weeks post‐injection |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐7.41, 7.41] |
13.3 14 to 26 weeks post‐injection |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐9.86, 9.86] |
14 Physician global assessment (0‐100 mm VAS where 100 is worst severity) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
14.1 1 to 4 weeks post‐injection |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
20.0 [7.27, 32.73] |
14.2 5 to 13 weeks post‐injection |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
20.00 [8.06, 31.94] |
14.3 14 to 26 weeks post‐injection |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [‐11.12, 11.12] |
15 WOMAC stiffness (0‐8 or 2‐10 Likert) |
2 |
|
Std. Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
15.1 1 to 4 weeks post‐injection |
2 |
81 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.01 [‐0.45, 0.43] |
15.2 5 to 13 weeks post‐injection |
1 |
41 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.34 [‐0.96, 0.27] |
15.3 14 to 26 weeks post‐injection |
1 |
41 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.47 [‐1.09, 0.15] |
16 Synovial fluid intercellular adhesion molecule‐1 (ICAM‐1) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
16.1 1 to 4 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.60 [‐5.67, 4.47] |
17 Synovial fluid vascular cell adhesion molecule‐1 (VCAM‐1) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
17.1 1 to 4 weeks post‐injection |
1 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.0 [‐10.23, 4.23] |
18 Safety: total withdrawals overall |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
19 Safety: withdrawals due to lack of efficacy |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
20 Safety: number of patients with local adverse event |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
21 Safety: withdrawals due to noncompliance |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |