Skip to main content
. 2006 Apr 19;2006(2):CD005321. doi: 10.1002/14651858.CD005321.pub2

Comparison 42. Orthovisc versus hylan G‐F 20.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 WOMAC pain (0‐20 or 5‐25 Likert) 3   Std. Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1 1 to 4 weeks post‐injection 3 121 Std. Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.29, 0.43]
1.2 5 to 13 weeks post‐injection 2 81 Std. Mean Difference (IV, Fixed, 95% CI) 0.28 [‐0.16, 0.73]
1.3 14 to 26 weeks post‐injection 2 81 Std. Mean Difference (IV, Fixed, 95% CI) 0.14 [‐0.29, 0.58]
1.4 37 weeks post‐injection 1 40 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.62, 0.62]
1.5 45 to 52 weeks post‐injection 1 40 Std. Mean Difference (IV, Fixed, 95% CI) 0.30 [‐0.32, 0.93]
2 Spontaneous pain (0‐100 mm VAS) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1 1 to 4 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐21.1 [‐33.08, ‐9.12]
2.2 5 to 13 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) 12.90 [0.85, 24.95]
2.3 14 to 26 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) 15.5 [0.80, 30.20]
2.4 37 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) 0.5 [‐11.67, 12.67]
2.5 45 to 52 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) 7.70 [‐3.94, 19.34]
3 SF‐36 pain 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.1 1 to 4 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐11.90 [‐25.49, 1.69]
3.2 5 to 13 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐30.80 [‐43.03, ‐18.57]
3.3 14 to 26 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐19.80 [‐35.52, ‐4.08]
3.4 37 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) 1.5 [‐7.67, 10.67]
3.5 45 to 52 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐9.0 [‐21.67, 3.67]
4 Hospital for Special Surgery Knee Score 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.1 1 to 4 weeks post‐injection 1 79 Mean Difference (IV, Fixed, 95% CI) ‐0.20 [‐4.04, 3.64]
4.2 5 to 13 weeks post‐injection 1 73 Mean Difference (IV, Fixed, 95% CI) 1.0 [‐3.04, 5.04]
4.3 14 to 26 weeks post‐injection 1 71 Mean Difference (IV, Fixed, 95% CI) ‐1.0 [‐5.65, 3.65]
4.4 45 to 52 weeks post‐injection 1 62 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐5.99, 5.79]
5 Pain during activity (Hospital for Special Surgery) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1 1 to 4 weeks post‐injection 1 79 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐1.71, 1.71]
5.2 5 to 13 weeks post‐injection 1 73 Mean Difference (IV, Fixed, 95% CI) 1.0 [‐0.79, 2.79]
5.3 14 to 26 weeks post‐injection 1 71 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐2.08, 1.88]
5.4 45 to 52 weeks post‐injection 1 62 Mean Difference (IV, Fixed, 95% CI) ‐0.30 [‐2.89, 2.29]
6 Pain at rest (Hospital for Special Surgery) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1 1 to 4 weeks post‐injection 1 79 Mean Difference (IV, Fixed, 95% CI) 1.10 [0.01, 2.19]
6.2 5 to 13 weeks post‐injection 1 73 Mean Difference (IV, Fixed, 95% CI) 0.20 [‐1.15, 1.55]
6.3 14 to 26 weeks post‐injection 1 71 Mean Difference (IV, Fixed, 95% CI) ‐0.30 [‐1.75, 1.15]
6.4 45 to 52 weeks post‐injection 1 62 Mean Difference (IV, Fixed, 95% CI) 0.30 [‐1.48, 2.08]
7 Pain during climbing stairs (Hospital for Special Surgery) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
7.1 1 to 4 weeks post‐injection 1 79 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐0.66, 0.66]
7.2 5 to 13 weeks post‐injection 1 73 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.79, 0.59]
7.3 14 to 26 weeks post‐injection 1 71 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.75, 0.55]
7.4 45 to 52 weeks post‐injection 1 62 Mean Difference (IV, Fixed, 95% CI) ‐0.40 [‐1.10, 0.30]
8 Pain during transfer activity (Hospital for Special Surgery) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
8.1 1 to 4 weeks post‐injection 1 79 Mean Difference (IV, Fixed, 95% CI) ‐0.20 [‐0.80, 0.40]
8.2 5 to 13 weeks post‐injection 1 73 Mean Difference (IV, Fixed, 95% CI) 0.40 [‐0.16, 0.96]
8.3 14 to 26 weeks post‐injection 1 71 Mean Difference (IV, Fixed, 95% CI) 0.10 [‐0.55, 0.75]
8.4 45 to 52 weeks post‐injection 1 62 Mean Difference (IV, Fixed, 95% CI) 0.20 [‐0.47, 0.87]
9 WOMAC physical function (0‐68 or 17‐85 Likert) 3   Std. Mean Difference (IV, Fixed, 95% CI) Subtotals only
9.1 1 to 4 weeks post‐injection 3 121 Std. Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.29, 0.43]
9.2 5 to 13 weeks post‐injection 2 81 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.13 [‐0.57, 0.31]
9.3 14 to 26 weeks post‐injection 2 81 Std. Mean Difference (IV, Fixed, 95% CI) 0.16 [‐0.28, 0.60]
9.4 37 weeks post‐injection 1 40 Std. Mean Difference (IV, Fixed, 95% CI) 0.08 [‐0.54, 0.70]
9.5 45 to 52 weeks post‐injection 1 40 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.72, 0.52]
10 SF‐36 physical functioning 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
10.1 1 to 4 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐1.00 [‐16.53, 10.53]
10.2 5 to 13 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐20.20 [‐29.47, ‐10.93]
10.3 14 to 26 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐11.20 [‐27.49, 5.09]
10.4 37 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) 4.20 [‐7.51, 15.91]
10.5 45 to 52 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐21.00 [‐35.97, ‐10.03]
11 Range of motion (degrees) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
11.1 1 to 4 weeks post‐injection 1 79 Mean Difference (IV, Fixed, 95% CI) 2.40 [‐2.69, 7.49]
11.2 5 to 13 weeks post‐injection 1 73 Mean Difference (IV, Fixed, 95% CI) 0.90 [‐2.87, 4.67]
11.3 14 to 26 weeks post‐injection 1 71 Mean Difference (IV, Fixed, 95% CI) ‐1.80 [‐6.48, 2.88]
11.4 45 to 52 weeks post‐injection 1 62 Mean Difference (IV, Fixed, 95% CI) 0.70 [‐4.52, 5.92]
12 Walking distance 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
12.1 1 to 4 weeks post‐injection 1 79 Mean Difference (IV, Fixed, 95% CI) ‐1.20 [‐2.49, 0.09]
12.2 5 to 13 weeks post‐injection 1 73 Mean Difference (IV, Fixed, 95% CI) ‐0.90 [‐2.11, 0.31]
12.3 14 to 26 weeks post‐injection 1 71 Mean Difference (IV, Fixed, 95% CI) ‐0.90 [‐2.07, 0.27]
12.4 45 to 52 weeks post‐injection 1 62 Mean Difference (IV, Fixed, 95% CI) ‐0.60 [‐1.92, 0.72]
13 Patient global assessment (0‐100 mm VAS where 100 is worst severity) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
13.1 1 to 4 weeks post‐injection 1 41 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐8.27, 8.27]
13.2 5 to 13 weeks post‐injection 1 41 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐7.41, 7.41]
13.3 14 to 26 weeks post‐injection 1 41 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐9.86, 9.86]
14 Physician global assessment (0‐100 mm VAS where 100 is worst severity) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
14.1 1 to 4 weeks post‐injection 1 41 Mean Difference (IV, Fixed, 95% CI) 20.0 [7.27, 32.73]
14.2 5 to 13 weeks post‐injection 1 41 Mean Difference (IV, Fixed, 95% CI) 20.00 [8.06, 31.94]
14.3 14 to 26 weeks post‐injection 1 41 Mean Difference (IV, Fixed, 95% CI) 0.0 [‐11.12, 11.12]
15 WOMAC stiffness (0‐8 or 2‐10 Likert) 2   Std. Mean Difference (IV, Fixed, 95% CI) Subtotals only
15.1 1 to 4 weeks post‐injection 2 81 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.01 [‐0.45, 0.43]
15.2 5 to 13 weeks post‐injection 1 41 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.34 [‐0.96, 0.27]
15.3 14 to 26 weeks post‐injection 1 41 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.47 [‐1.09, 0.15]
16 Synovial fluid intercellular adhesion molecule‐1 (ICAM‐1) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
16.1 1 to 4 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐0.60 [‐5.67, 4.47]
17 Synovial fluid vascular cell adhesion molecule‐1 (VCAM‐1) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
17.1 1 to 4 weeks post‐injection 1 40 Mean Difference (IV, Fixed, 95% CI) ‐3.0 [‐10.23, 4.23]
18 Safety: total withdrawals overall 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
19 Safety: withdrawals due to lack of efficacy 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
20 Safety: number of patients with local adverse event 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
21 Safety: withdrawals due to noncompliance 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only