| Methods |
Randomised
Controlled
Trial
Single centre
Parallel‐group |
| Participants |
Country:
England
Mean age: 62
% Female: NR
Disease duration: NR
Duration: 1 yr
Number randomised: 38
(HA 19, AR 19)
Inclusion:
Symptomatic knee OA with radiographic evidence of some remaining joint space on weight bearing films
Be fit for regional or general anaesthesia.
Exclusion:
Pts with mechanical symptoms
IA injection within last 6 mths
Previous arthro‐
scopic surgery
Hypersensitivity to avian proteins
Baseline:
Pain
HA: 7.6
AR: 7.5
Lequesne
HA: 10.5
AR: 13.0
Knee Society ftn:
HA: 65
AR: 45 |
| Interventions |
Hyalgan
20 mg
5 weekly injections
Arthroscopic washout with either general or spinal anaesthesia 2 l 0.9% saline at least |
| Outcomes |
Pain (10 cm VAS)
Function score from the Knee Society rating system
Lequesne |
| Notes |
Jadad's:3/5
R‐2,B‐0,W‐1
The Knee Society function score was significantly worse in the AR group at baseline. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
