Karras 2001.

Methods	Randomised Controlled Trial Parallel‐group SIngle centre
Participants	Country: Greece Mean age: NR % Female: NR Disease duration: NR Duration: 1 y Number randomised: 200 (HA5: NR HA3: NR ) Inclusion: Suffering from OA of the knee Exclusion: NR Baseline values: NR
Interventions	Hyalgan 5 weekly injections every 6 months Hyalgan 3 weekly injections every 3 months
Outcomes	Lequesne, Pain (VAS), Clinical response by pt and physician.
Notes	Jadad's:2/5
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear