| Participants |
Country:
China
Mean age: 69
% Female: 28
Mean disease
duration: 19 mth
Duration: 26 wk
Number randomised: 90
[116 knees: Artz 62, PL 54]
Inclusion:
adults diagnosed as early OA (mild to moderate) by 4 senior orthopedic surgeons
clinical symptoms with exercise pain, limitation of joint function and radiologic findings of bone spur, JSN, or osteosclerosis
Exclusion:
steroid IA injection
functional disturbance of liver and kidney
pregnancy
severe degeneration of knee joints with marked joint narrowing, marked varus or valgus deformity or a large amount synovial effusion
Baseline values:
% pt moderate
walking pain
Artz: 36, PL:41
% pt mild rest pain
Artz:53, PL:54 |
| Outcomes |
pain: rest, walking, up/down stairs, flexion and extension, oppressive; swelling, ballote‐
ment of patella
(4 grades: no symptoms, mild, moderate,severe symptoms);
synovial fluid (vol), range of motion (degrees), actvities of daily living (walk 10 min, up/down stairs,squat to pick up some‐
thing, sitting on floor) impair‐
ment (1:no problem to do,2=
fairly possible to
do alone,3=pos‐
sible to do but
often with incon‐
venience,4=need
help,5=complete
ly impossible)
radiographic
change (mild,
moderate,severe), general
improvement by pt and MD (1‐7:
excellent improvement,
improved, fair
improvement, unchanged,
slightly worsened, wor‐
sened, markedly
worsened),
overall evaluation
effectiveness (1‐7:excellent improvement, improved, fair improvement, no change, slightly
worsened, wor‐
sened, extremely
worsened), usefulness
(1‐7: extremely good, good, fairly
good, uncertain,
slightly unfavor‐
able, unfavor‐
able, extremely unfavorable), and safety (1‐3):no
side effect, side
effect but treat‐
ment continued,
stop treatment due to side effect |
