| Participants |
Phase IV randomised, double‐blind, placebo controlled, parallel group
Inclusion criteria:
12 criteria:
written consent,
40 yr of age and above,
of sufficient good health to be able to complet 6‐month follow‐up,
signs and symptoms of OA of at least one knee according to ACR criteria,
Kellgren‐Lawrence Grade II or III,
symptoms including knee joint pain, crepitus, swelling, and/or effusion of the knee for at least 6 mths,
pts on analgesic/NSAID VAS pain score after walking on a 50 foot flat surface of greater than or equal to 30 mm but less than 90 mm,
if not taking analgesic/NSAIDVAS pain score after walking of greater than 40 mm but less than 90 mm,
if bilateral knee pain is present, investigator will select the more painful knee
Exclusion criteria:
4 general,
28 musculoskeletal related,
16 concomitant conditions, diseases, medications and/or clinical history related |
