Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 14;13:814291. doi: 10.3389/fgene.2022.814291

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Liu, Shen, He and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Immunity analyses of CTD-2288O8.1 in OC. (A) Single gene GSEA of CTD-2288O8.1 (GO term and KEGG pathways). (B) Correlation of CTD-2288O8.1 with EstimateScore, ImmuneScore, and StromalScore, Wilcoxon rank sum was applied for the significance test. (C) qRT- PCR showing CTD-2288O8.1 promoted the expression of M2 markers (TGF-β, IL-10, CD163, and CD206) in M2 macrophages (left). Coculture assay showed CTD-2288O8.1 overexpressed in SKOV3 promoted the expression of M2 markers (ARG1, TGF-β, IL-10, and CD206) in M2 macrophages (right). (D) Correlation between common inhibitory immune checkpoints and CTD-2288O8.1 high- and low-expression cohorts. (E) Correlation analysis of CTD-22888O8.1 expression and immune checkpoint genes. (F) qRT-PCR showing the RNA level of CTD-2288O8.1 was positively correlated with PD-L1, LAG3, and PD-L2. *p-value < 0.05, **p-value < 0.01, ***p-value < 0.001, and ****p-value < 0.0001.