Frías 2004.

Methods	Randomised controlled trial 2‐arm parallel‐group design Trial duration: 12 weeks
Participants	299 knees belonging to 205 participants with knee osteoarthritis were randomised 299 knees belonging to 205 participants were reported at baseline Number of females: 234 (78%) of 299 knees belonged to female participants Mean age: 67.0 years
Interventions	Experimental intervention 40 mg triamcinolone acetonide plus lavage (3 L of cold (8°C) saline), single intra‐articular application Control intervention Lavage (3 L of cold (8°C) saline), single intra‐articular application
Outcomes	Extracted pain outcome: Pain overall Maximum follow‐up: 12 weeks
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method used to generate random sequence of allocation was not reported, so the risk of selection bias was unclear
Allocation concealment (selection bias)	Unclear risk	Method used to conceal the random sequence of allocation was not reported, so the risk of selection bias was unclear
Blinding of participants?	Unclear risk	Although the authors stated "Glucocorticoid treatment with triamcinolone acetonide was always given on a blind basis", they also stated that this was an open trial (Quote: "The study was of the longitudinal, open, prospective, controlled type").The risk of performance bias was therefore considered unclear
Blinding of health care provider(s)	Unclear risk	Although the authors stated "Glucocorticoid treatment with triamcinolone acetonide was always given on a blind basis", they also stated that this was an open trial (Quote: "The study was of the longitudinal, open, prospective, controlled type"). The risk of performance bias was therefore considered unclear
Intention‐to‐treat analysis performed? Pain	High risk	82 of 299 knees were excluded at 1 month, 51 of 299 knees were excluded at 3 months
Intention‐to‐treat analysis performed? Function	Unclear risk	Not applicable, no function outcome reported