Table 3.
Characteristics of Crohn’s disease (CD) and fertility parameters according to AMH
| AMH≥1.77 ug/l, n=31 | AMH<1.77 ug/l, n=19 | P value | |
|---|---|---|---|
| median [25–75P] or n (%) | |||
| Age, y | 29.00 [25.50, 32.00] | 39.00 [33.50, 42.00] | <0.001 |
| Body mass index, kg/m 2 | 20.20 [19.00, 21.62] | 21.62 [20.47, 23.14] | 0.122 |
| Smoking, n (%) | 9 (29.0) | 7 (38.9) | 0.537 |
| Age of CD dg, y | 22.00 [17.50, 25.00] | 27.00 [24.00, 31.00] | 0.002 |
| CD duration, y | 8.00 [4.00, 11.00] | 10.00 [4.50, 14.00] | 0.217 |
| CD dg. <5 years, n (%) | 13 (41.9) | 6 (31.6) | 0.556 |
| CD phenotype * | |||
| B1, n (%) | 17 (54.8) | 10 (52.6) | 1.000 |
| B2, n (%) | 10 (32.3) | 4 (21.1) | 0.522 |
| B3, n (%) | 4 (12.9) | 5 (26.3) | 0.273 |
| L1, n (%) | 17 (54.8) | 7 (36.8) | 0.255 |
| L2, n (%) | 3 (9.7) | 6 (31.6) | 0.067 |
| L3, n (%) | 11 (35.5) | 6 (31.6) | 1.000 |
| Serum creatinine, umol/l | 56.30 [50.70, 61.00] | 62.10 [56.05, 65.70] | 0.089 |
| Disease activity | |||
| Quality of life score (SIBDQ) | 59.00 [46.00, 67.00] | 64.00 [52.75, 67.50] | 0.398 |
| Harvey-Bradshaw index | 2.00 [0.00, 4.50] | 0.00 [0.00, 2.00] | 0.115 |
| Stool calprotectin, ug/g | 69.10 [43.23, 190.25] | 64.00 [15.25, 153.00] | 0.424 |
| C-reactive protein, mg/l | 2.08 [0.92, 7.95] | 2.00 [0.38, 2.80] | 0.232 |
| White blood cells, ×10.9/l | 7.84 [5.97, 9.56] | 6.91 [5.72, 8.82] | 0.602 |
| Therapy | 2 (6.7) | 0 (0.0) | |
| steroids, n (%) | 2 (6.7) | 0 (0.0) | 0.528 |
| aminosalicylates, n (%) | 18 (58.1) | 12 (63.2) | 0.774 |
| azathioprine, n (%) | 19 (61.3) | 10 (52.6) | 0.570 |
| anti-TNF alpha, n (%) | 18 (58.1) | 12 (63.2) | 0.774 |
| anti-TNF alpha ever, n (%) | 22 (73.3) | 12 (70.6) | 1.000 |
| IBD surgery, n (%) | 12 (38.7) | 8 (42.1) | 1.000 |
| Reproductive health | |||
| Irregular menstrual cycle, n (%) | 10 (32.3) | 4 (23.5) | 0.741 |
| Hirsutism, n (%) | 2 (6.9) | 2 (11.8) | 0.619 |
| Spontaneous abortion, n (%) | 0 (0.0) | 3 (16.7) | 0.062 |
| At-risk pregnancy, n (%) | 0 (0.0) | 3 (17.6) | 0.095 |
| Preterm delivery, n (%) | 1 (5.6) | 2 (11.8) | 0.603 |
| Induced abortion, n (%) | 2 (7.7) | 4 (22.2) | 0.208 |
| Deliveries, n | 0.00 [0.00, 1.00] | 1.00 [1.00, 1.50] | 0.016 |
| 0, n (%) | 18 (58.1) | 4 (21.1) | 0.043 |
| 1, n (%) | 9 (29.0) | 10 (52.6) | |
| 2, n (%) | 4 (12.9) | 5 (26.3) | |
| Gynecological surgery, n (%) | 5 (17.2) | 6 (33.3) | 0.291 |
| Contraception, n (%) | 6 (19.4) | 1 (5.9) | 0.396 |
| In-vitro fertilization, n (%) | 0 (0.0) | 0 (0.0) | 1.000 |
*
Vienna classification: Localisation: L1 terminal ileum, L2 colon, L3 ileocolon, Behavior: B1 inflammatory, B2 stricturizing, B3 penetrating