TABLE 1.

miRNA involved in the regulation of pyroptosis-related molecules.

miRNA	Model	Signaling pathways/Target	Result	References
miR-20a	Human aortic endothelial cells (HAECS)	TLR、TXNIP	Negatively regulates TLR4 and NLRP3 signaling to protect HAECs from inflammatory injuries, inhibits the atherosclerotic development	Chen et al. (2018)
miR-30c-5p	HAECs	FOXO3	Inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis, anti-atherosclerosis	Li et al. (2018)
miR-125a-5p	Human umbilical vein endothelial cells	TET2	Activates NLRP3 inflammasome and caspase-1, promotes pyroptosis and atherosclerosis progression	Zhaolin et al. (2019b)
	Human vascular smooth muscle cells	CCL4	Inhibits expression of NLRP3、ASC、caspase-1 and IL-1β proteins, anti-atherosclerosis	Jiawang Wang et al. (2019)
miR-223	Primary macrophages	NLRP3	Inhibits NLRP3 inflammasome	Bauernfeind et al. (2012)
miR-9	Human THP-1 derived macrophages	JAK1/STAT1	Inhibits activation of the NLRP3 inflammasome, attenuates atherosclerosis-related inflammation	Wang et al. (2017)
miR-181a	THP‐1 macrophages	MEK1	Inhibits the expression of NLRP3 inflammasome-related proteins, alleviates pyroptosis	Song et al. (2019)
miR-33	Bone marrow derived macrophages, Ldlr −/− mice	Prkaa1	Promotes pyroptosis and atherosclerosis progression	Tumurkhuu et al. (2016)
miR-155	THP-1 macrophages, ApoE−/- mice	ERK1/2	Increases the expression of NLRP3 inflammasome and the secretion of IL-1β and IL-18, aggravates the carotid atherosclerosis lesion	Yin et al. (2019)
miR-145	Vascular smooth muscle cells, ApoE−/- mice	CD137/NFATc1	Inhibits NLRP3 inflammasome and pyroptosis, increases the stability of atherosclerosis lesions	Zhong et al. (2018)

TLR, toll-like receptors; TXNIP, thioredoxin-interacting protein; FOXO3, Forkhead box O3; TET, ten-eleven translocation; CCL4, C-C motif chemokine 4-like; JAK1, Janus kinase 1; MEK1, MAP, kinase 1; Prkaa1, AMP, kinase; NFATc1, nuclear factor of activated T cells1.