Figure 1.

miR-338-3p is downregulated in pulmonary fibrosis. A: human lung tissue from nonfibrotic donors (n = 3 subjects) and donors with IPF (n = 10 subjects; patient characteristics listed in Table 1) was analyzed for miR338-3p expression. B: mice (n = 7 mice/group) were treated with vehicle or 1.5 U/kg bleomycin by oropharyngeal aspiration and lung tissue was harvested after 21 days. C: lung tissue from mice exposed to a single dose of 5 Gy total body and 10 Gy thoracic radiation (n = 7–9 mice/group) were harvested 26 wk after exposure and tissue was analyzed for miR-338-3p. All data was analyzed by t test (**P < 0.01, ***P < 0.005).