Fig 8. Results and observation of the dose finding study.

A) The mean initiation of the wound healing after each dose and frequency combination, B) incidence of wound infections during the study and C) the peri-wound inflammation and erosion events observed in the animals. Data presented as mean ± SEM (A) or as individual number of findings (B & C). The data were not statistically analysed. Est. = estimated mean value for vehicle wound healing initiation as most of the wounds were not healing by the end of the study. For such wounds, the termination date (day 20) was used as value for the calculations.