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. 2022 Feb 24;15:1331–1345. doi: 10.2147/JIR.S354095

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© 2022 Frühbeck et al.

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Serum IL-1RA correlates with leptin and adiponectin and with the marker of dysfunctional adipose tissue adiponectin/leptin (Adpn/Lep) ratio. Comparison of fasting serum concentrations of (A) leptin, (B) adiponectin, and (C) Adpn/Lep ratio in subjects with normal weight (NW), obesity and normoglycemia (OB-NG), and obesity and impaired glucose tolerance or T2D (OB-IGT&T2D). Bars represent the mean ± SD. Statistical differences between groups were analyzed by ANOVA followed by LSD tests. ***P<0.001. Scatter diagrams showing the correlations between the circulating concentrations of IL-1RA with the levels of (D) leptin, (E) adiponectin, and (F) the Adpn/Lep ratio. Pearson’s correlation coefficient (r) and P values are indicated. The y-axis is shown in log scale in (F) and horizontal discontinuous lines denote the Adpn/Lep ratio proposed cut-offs of 0.5 and 1.0.⁵⁰^,⁵¹