A) Energy expenditure (EE) over time, B) total EE during the light cycle, dark cycle, and full 24 hour cycle, C) activity over time, and D) total activity during the light cycle, dark cycle, and full 24 hour cycle. **p<0.01 compared with S-AL; +p<0.05, ++p<0.01 compared with S-WM; #p<0.05 compared with S-AL-WT by three-factor ANOVA and ANCOVA (using total body mass as the co-variate).