Table 2.

Characteristics of patients with multiple molecular classifiers

	Age at time of diagnosis	Multiple-classifier EC	POLE variant	Tumor type	FIGO stage	Lymphovascular invasion	Clinical risk assessment
Patient 1	76	POLEmut and p53abn	P286R	endometrioid	IIIC2	Yes	High
Patient 2	75	POLEmut and p53abn	P286R	carcinosarcoma	IB	Yes	High
Patient 3	70	MMRd and p53abn	wild-type	endometrioid	IA	No	Low
Patient 4	87	MMRd and p53abn	wild-type	endometrioid	IIIB	Yes	High
Patient 5	53	POLEmut and p53abn	P286R	endometrioid	IA	No	Low
Patient 6	52	POLEmut and p53abn	P286R	endometrioid	IA	No	Intermediate

MMRd = mismatch repair deficient tumour; p53abn = p53 expression abnormal tumour; POLE = DNA polymerase-epsilon; POLEmut = POLE ultramutated tumour