Figure 7. AAV9/MFSD8 GT restores impaired behavioral phenotypes in KO mice.

High (5 × 10¹¹ vg/mouse) or low (1.25 × 10¹¹ vg/mouse) dose of AAV9/MFSD8 vector was administered i.t. to equal numbers of male and female mice at P7–P10 or P120. The mice were allowed to complete rotarod (A), open-field (B–D), marble-burying (E), and wire-hang (F) tests. All data are presented as mean ± SEM (n = 16–40). Data sets of each time point that passed tests for normality or homogeneity of variance were analyzed using 1-way ANOVA with α set at 0.05 and Dunnett’s correction for relevant pairwise comparisons. Data sets that did not pass tests for normality or homogeneity of variance were analyzed using the Kruskal-Wallis test with α set at 0.05 and Dunn’s correction for relevant pairwise comparisons. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, compared with KO-Veh.