Table 2.
Differential abundance genus associated with CIN in cervix detected by multivariate analysis.
| Phylum | Class | Order | Family | Genus | HC a | CIN a | log2FC | p | pm | pmadj |
|---|---|---|---|---|---|---|---|---|---|---|
| Proteobacteria | Betaproteobacteria | Burkholderiales | Comamonadaceae | Comamonas | 0.38 | 0.38 | −0.02 | 2.50E−02 | 2.58E−05 | 5.59E−03 |
| Proteobacteria | Alphaproteobacteria | Rhizobiales | Rhizobiaceae | Rhizobium | 0.07 | 0.13 | 0.86 | 3.04E−01 | 3.78E−05 | 5.59E−03 |
| Proteobacteria | Gammaproteobacteria | Pseudomonadales | Pseudomonadaceae | Pseudomonas | 0.17 | 0.89 | 2.39 | 4.46E−01 | 6.61E−04 | 4.89E−02 |
| Proteobacteria | Alphaproteobacteria | Caulobacterales | Caulobacteraceae | Brevundimonas | 0.04 | 0.10 | 1.34 | 5.02E−05 | 1.02E−03 | 5.02E−02 |
| Proteobacteria | Betaproteobacteria | Methylophilales | Methylophilaceae | Methylophilus | 0.08 | 0.09 | 0.17 | 1.39E−03 | 2.10E−03 | 8.76E−02 |
| Proteobacteria | Betaproteobacteria | Burkholderiales | Ralstonia_f | Ralstonia | 0.13 | 0.02 | −2.91 | 5.75E−01 | 2.37E−03 | 8.76E−02 |
| Proteobacteria | Betaproteobacteria | Burkholderiales | Comamonadaceae | Curvibacter | 0.04 | 0.08 | 0.96 | 8.86E−04 | 3.71E−03 | 1.00E−01 |
| Proteobacteria | Betaproteobacteria | Methylophilales | Methylophilaceae | Other | 0.02 | 0.02 | 0.17 | 1.03E−01 | 3.72E−03 | 1.00E−01 |
| Proteobacteria | Betaproteobacteria | Burkholderiales | Comamonadaceae | Aquabacterium | 0.05 | 0.09 | 0.96 | 1.31E−02 | 4.80E−03 | 1.09E−01 |
| Proteobacteria | Deltaproteobacteria | Bdellovibrionales | Bacteriovoracaceae | Peredibacter | 0.01 | 0.07 | 2.32 | 9.16E−03 | 7.68E−03 | 1.51E−01 |
| Proteobacteria | Gammaproteobacteria | Pseudomonadales | Moraxellaceae | Enhydrobacter | 0.05 | 0.02 | −1.02 | 5.45E−01 | 9.37E−03 | 1.70E−01 |
| Fusobacteria | Fusobacteria_c | Fusobacteriales | Fusobacteriaceae | Fusobacterium | 0.03 | 0.03 | 0.17 | 5.13E−01 | 9.75E−03 | 1.70E−01 |
| Firmicutes | Bacilli | Lactobacillales | Aerococcaceae | Granulicatella | 0.02 | 0.03 | 0.69 | 9.04E−02 | 1.46E−02 | 2.41E−01 |
p, univariate p-values derived from Wilcoxon rank-sum test; pm, multivariate p-values derived from MaAsLin, adjusting for age, BMI, onset of sexual activity, and HPV infection; pmad, FDR-corrected multivariate p-values to account for multiple testing.
CIN, cervical intraepithelial neoplasia; HC, healthy control; MaAsLin, multivariate analysis with linear models; BMI, body mass index; HPV, human papillomavirus; FDR, false discovery rate.
a
Mean relative abundance of genus in HC and CIN in terms of percentage (%).