Figure 7.

The potential treatment of natural polyphenols in neurodegenerative diseases. The natural plants especially the dietary food, such as grape, green tee, and litchi, enrich polyphenols, together with the widely reported polyphenols, such as resveratrol, curcumin, and quercetin, exhibit potent neuroprotective effects mainly involving inhibition of neuronal death and glial overactivation. The molecular mechanisms associated with the progress of neurogenerative diseases (AD, PD, HD, ALS, MS, etc.) include DNA damage, mitochondrial dysfunction, oxidative stress, excitotoxicity, biometal dyshomeostasis, neurotrophic impairment, neuroinflammatory responses, and the aggregation of misfolded proteins.