(a).

Patients non-R	0 months (T0)	6 months (T1)	12 months (T2)	18 months (T3)	24 months (T4)
1	33.88	33.84	33.23	33.7	33.81
2	33.81	33.27	32.58	32.39	32.48
3	32.51	31.93	31.98	32.01	32.19
4	32.47	32.5	32.54	31.88	32.18
5	32.26	32.84	32.88	32.49	32.75
8	32.04	32.01	31.58	31.87	31.82