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. 2021 Dec 23;18(3):264–271. doi: 10.1038/s41589-021-00918-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Sequence alignment of nine human endogenous CCR1 agonists and other CCR1 non-agonists. The sequences of CRS1, CRS2 and CRS3 regions were highlighted in yellow, red and blue, respectively. And the positions which share fully conserved residues were marked with red circles. Residues with strongly similar properties (scoring > 0.5 in the Gonnet PAM 250 matrix) were marked with yellow circles. Residues with weakly similar properties (scoring < 0.5 in the Gonnet PAM 250 matrix) were marked with green circles.