Table 3. Multivariate linear regression analyses of subgroups associated with sACE2 and sTMPRSS2.
| Variables | Ln (ACE2) | Ln (TMPRSS2) | ||
|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | |
| Age, < 70 vs. ≥ 70 | −0.135 (−0.261, −0.01) | 0.035 | 0.164 (−0.165, 0.493) | 0.328 |
| Male, vs. female | −0.168 (−0.416, 0.08) | 0.183 | ||
| Never-smoker vs. ever-smoker | 0.128 (−0.119, 0.375) | 0.308 | ||
| Blood eosinophil count cells/µL, < 200 vs. ≥ 200 | 0.085 (−0.001, 0.172) | 0.054 | −0.152 (−0.364, 0.06) | 0.160 |
| FEV1/FVC, < 0.6 vs. ≥ 0.6 | −0.184 (−0.483, 0.115) | 0.227 | ||
| HTN, no vs. yes | 0.269 (−0.017, 0.554) | 0.065 | ||
| Use of ICS on sampling time, non-use vs. use | −0.103 (−0.189, −0.018) | 0.018 | ||
ACE2 = angiotensin-converting enzyme 2, TMPRSS2 = transmembrane protease serine subtype 2, sACE2 = soluble ACE2, sTMPRSS2 = soluble form of TMPRSS2, CI = confidence interval, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity, HTN = hypertension, ICS = inhaled corticosteroids.