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. 2022 Feb 15;8:683445. doi: 10.3389/fcvm.2021.683445

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Copyright © 2022 Yang, Xiao, Du, Chen, Ni, Guo, Xue and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic significance of circulating NET markers for predicting in-hospital death and 1-year survival of AAD patients. (A) Serum levels of citH3, cfDNA and nucleosomes in patients with in-hospital death were significantly higher than those in patients without in-hospital death. (B) AAD patients with the highest quartiles of citH3, cfDNA or nucleosome levels presented significantly lower survival rates by 1 year than patients with the lower three quartiles of citH3. (C) Based on the ROC curve, three circulating NET markers showed superior prediction ability of 1-year survival compared with D-dimer. ^*P < 0.05, ^**P < 0.01.