Fig. 1.

Metabolism and mechanism of action of fluoropyrimidines. 5-FU 5-fluorouracil, 5′dFCR 5′-deoxy-5-fluorocytidine, 5′dFUR 5′-desoxy-5-fluorouridine, CDA cytidine deaminase, CES carboxylesterases, CYP2A6 cytochrome P450 2a6, DHF dihydrofolate, DHFU dihydrofluorouracil, DPD dihydropyrimidine dehydrogenase, dTMP deoxythymidine monophosphate, dUMP deoxyuridine monophosphate, FBAL α -fluoro-β-alanine, FdUDP fluorodeoxyuridine diphosphate, FdUMP fluorodeoxyuridine monophosphate, FdUTP fluorodeoxyuridine triphosphate, FUDP fluorouridine diphosphate, FUDR fluorodeoxyuridine, FUMP fluorouridine monophosphate, FUPA 5-fluoro-ureidopropionic acid, FUTP fluorouridine triphosphate, MTHF 5,10-methylene tetrahydrofolate, TP thymidine phosphorylase, TS thymidylate synthase