Table 4.
Top 20 Differentially Methylated Loci in Associated with cLBP in NHBs versus NHWs.
| Chr | Position | Beta | SE | 95% CI |
P-value | q-value | Genes | Gene Name/Description | Genomic Features | |
|---|---|---|---|---|---|---|---|---|---|---|
| LL | UL | |||||||||
| 1 | 1,419,278 | 0.76 | 0.05 | 0.66 | 0.87 | 1.20E-18 | 3.12E-12 | ATAD3B | ATPase Family AAA Domain Containing 3B | intergenic |
| 17 | 36,590,735 | 0.71 | 0.05 | 0.60 | 0.81 | 8.82E-18 | 1.14E-11 | ARHGAP23 | Rho GTPase Activating Protein 23 | intergenic |
| 18 | 11,550,683 | 0.69 | 0.06 | 0.58 | 0.81 | 3.69E-16 | 3.19E-10 | RP11-712C7.2 | Long-noncoding RNA | intergenic |
| 5 | 176,190,238 | −0.67 | 0.06 | −0.78 | −0.56 | 7.66E-16 | 4.97E-10 | intergenic | ||
| 1 | 53,970,911 | 0.72 | 0.06 | 0.60 | 0.85 | 1.68E-15 | 8.74E-10 | GLIS1 | GLIS Family Zinc Finger 1 | intergenic |
| 19 | 4,028,691 | 0.70 | 0.06 | 0.57 | 0.83 | 1.93E-14 | 8.37E-09 | PIAS4 | Protein Inhibitor Of Activated STAT 4 | intergenic |
| 6 | 95,534,202 | 0.73 | 0.07 | 0.59 | 0.86 | 3.08E-14 | 1.14E-08 | intergenic | ||
| 1 | 160,347,421 | 0.68 | 0.06 | 0.55 | 0.80 | 4.60E-14 | 1.39E-08 | NHLH1 | Nescient Helix-Loop-Helix 1 | intergenic |
| 12 | 50,862,234 | −0.73 | 0.07 | −0.87 | −0.59 | 4.80E-14 | 1.39E-08 | LARP4 | La Ribonucleoprotein 4 | intergenic |
| 20 | 62,149,177 | 0.64 | 0.06 | 0.52 | 0.76 | 6.01E-14 | 1.56E-08 | PPDPF | Pancreatic Progenitor Cell Differentiation And Proliferation Factor | intergenic |
| 18 | 71,841,430 | −0.61 | 0.06 | −0.73 | −0.49 | 1.47E-13 | 3.48E-08 | intergenic | ||
| 10 | 127,291,526 | 0.61 | 0.06 | 0.49 | 0.73 | 2.82E-13 | 6.10E-08 | TEX36 | Testis Expressed 36 | introns |
| 4 | 177,637,599 | −0.54 | 0.06 | −0.66 | −0.43 | 6.64E-13 | 1.33E-07 | VEGFC | Vascular Endothelial Growth Factor C | intergenic |
| 10 | 128,944,081 | −0.64 | 0.07 | −0.77 | −0.51 | 7.26E-13 | 1.35E-07 | DOCK1 | Dedicator Of Cytokinesis 1 | introns |
| 15 | 74,592,862 | −0.60 | 0.06 | −0.73 | −0.48 | 1.10E-12 | 1.82E-07 | CCDC33 | Coiled-Coil Domain Containing 33 | intergenic |
| 2 | 195,597,960 | 0.38 | 0.04 | 0.30 | 0.46 | 1.12E-12 | 1.82E-07 | AC006196.1 | Long non-coding RNA | intergenic |
| 19 | 51,801,429 | 0.67 | 0.07 | 0.53 | 0.81 | 1.51E-12 | 2.30E-07 | intergenic | ||
| 4 | 3,578,876 | 0.36 | 0.04 | 0.28 | 0.44 | 3.67E-12 | 5.28E-07 | LINC00955 | Long non-coding RNA | promoters |
| 1 | 11,395,415 | 0.67 | 0.07 | 0.52 | 0.81 | 3.86E-12 | 5.28E-07 | intergenic | ||
| 1 | 16,455,052 | −0.64 | 0.07 | −0.78 | −0.50 | 5.51E-12 | 7.16E-07 | EPHA2 | Ephrin type A receptor 2 | intergenic |
Notes: Chr = chromosome, CI = confidence interval; LL = lower limit of the confidence interval; UL = upper limit of the confidence interval; SE = standard error; cLBP = chronic low back pain; NHW = non-Hispanic White; NHBs = non-Hispanic Blacks.