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Regulation of metabolic rewiring upon macrophage cells activation. The TAM-derived hypoxia and glucose metabolism products favor neoangiogenesis through endothelial growth factor A (VEGFA), adrenomedullin (AMD), C-X-C motif chemokine ligand 8 (CXCL8), and CXCL12. In the meantime, the FABP5 and the metabolite of glycolysis favor the tumor progression by expression of IL-6 and PD-L1 through NF-κB pathway signaling inhibiting CD8+ T cells anti-tumor effects.
