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. 2022 Feb 28;7:18. doi: 10.1038/s41536-022-00213-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Time lapse of the a angiography and b urography images of the matrix-implanted kidney. The white arrowheads show the regions where the contrast was enhanced in the matrix. c Photographs of (top) a kidney containing an organ-derived matrix sutured to residual kidney before harvest 28 days post-implantation and (bottom) the harvested and sagittally resected kidney. The direction of the kidneys is identical to that of the kidneys imaged in Fig. 6a and b. d H&E staining of the area surrounded by the black-dotted circle in Fig. 6c. The area within the black-dotted circle in Fig. 6d shows the region where the matrix, residual kidney, and fused renal capsule are closely packed. Scale bar: 2 mm. e CT images of the matrix-implanted kidney. The white arrows show the matrix. f, g Time course of the CT scan images for f the PN kidney and g the matrix-implanted kidney. The white arrowheads show the matrix. h Time course of the mean CT number in the renal cortex, renal pelvis, and matrix in the implanted kidney. The CT number in ROI was estimated using OsiriX Lite. The white-dotted blue circles indicate ROI in the renal cortex, renal pelvis, and matrix. Bars represent the mean ± SD, (n = 3).