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. 2022 Feb 28;12:3315. doi: 10.1038/s41598-022-07365-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Social Interaction Does Not Differ Following Insula Inhibition. (A) Rats underwent a social reward place conditioning task. On preconditioning day 1, rats were placed in the open field and given 10 min to explore the environment. On conditioning days 2–4, Observers were injected with water or CNO 30 min prior to the task in a between subject’s design and given the opportunity to explore an unfamiliar rat and an unfamiliar object simultaneously. Finally, on day 5, rats were returned to the empty open field for a post-conditioning assessment. Time spent in the social zone (SZ) and the object zone (OZ) were recorded. (B) Rats did not exhibit a side bias within the open field, equally preferring the SZ and OZ on pre-conditioning day. (C) On conditioning days, a main effect of zone was observed in which all groups preferred the SZ over the OZ. (D) During post-conditioning day 5, a main effect of side was again observed, in which the time spent in the SZ was greater than the OZ. However, all groups equally preferred the SZ over the OZ. *Significant effect of zone, p < 0.05.