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. 2022 Feb 28;13:1087. doi: 10.1038/s41467-022-28721-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a A representative crystal structure of N-Mdm2 in complex with nutlin-3a (red line). b The structure N-MdmX/nutlin-3a complexes (in purple) are superimposed on those of the N-Mdm2/nutline-3a complexes (in yellow). c Comparison of major side-chain configurations between the F19^p53p subsites of N-MdmX and N-Mdm2. d A 2Fo-Fc map contoured at 1.5 σ of a section of the H72 side chain on N-Mdm2 revealing two configurations. e, f Comparison of major side chain configurations in the W23^p53p and L26^p53p subsites, respectively, between N-MdmX and N-Mdm2.