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. 2022 Feb 28;13:1087. doi: 10.1038/s41467-022-28721-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Treatment of cancer cells with H203 induced the expression of the p21 gene but not the p53 gene. Solid and open symbols indicate p21 and p53 transcription levels, respectively. Triangle: H460a cell; circle: RKO cell; and square: HCT116 cell. n = 3 independent experiments, and the data are represented as mean values ± SD. b–e The viability of the H1299 cells overexpressing Mdm2 and/or MdmX was significantly influenced by H203 compared with nutlin-3a and nutlin-3b. Empty bar: nutlin-3a (a positive control); gray bar: nutlin-3b (a negative control); and dark bar: H203. H1299^{p53+/Mdm2+/MdmX+} cells (b); H1299^{p53+/Mdm2+/MdmX-} cells (c); H1299^{p53+/Mdm2-/MdmX+} cells (d); and H1299^{p53+/Mdm2-/MdmX−} cells (e). n = 3 independent experiments and the data are represented as mean values ± SD. Source data for (a–e) are provided as a Source Data file.