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. 2022 Feb 28;12:3335. doi: 10.1038/s41598-022-07410-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Clustered column for Ti (chart on the left) and SEVR (chart on the right) from baseline to Recovery; significant difference observed for Ti from baseline to PEEP = 10 cmH₂O and from baseline to recovery; significant increase also for SEVR from baseline to the application of PEEP = 5 cmH₂O and from baseline to the application of PEEP = 10 cmH₂O. Data are presented as mean, error bars represent standard deviation. CTR, percentage of changes in comparison to control; Ti, time to inflection point; SVER, diastolic AUC divided by systolic-AUC (Buckberg index). *p values < 0.05, statistically significant. **p values < 0.01.