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. 2022 Feb 28;8:90. doi: 10.1038/s41420-022-00894-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b Concentration of biochemical indicators CK and myoglobin in serum. c HE staining analyses the pathological changes of muscle in the CS group (original magnification: 200×; scale bar: 100 μm). d, e Concentration of biochemical indicators SCr and BUN in serum. f, g qPCR analyses KIM-1 and NGAL mRNA level at the CS group. h HE and PAS staining analyze the pathological changes of renal tissues in the CS group (original magnification: 200×; scale bar: 100 μm). i IHC staining for myoglobin in the CS group, IgG as a negative control (original magnification: 200×; scale bar: 100 μm). j Representative anti-F4/80 staining showing increased macrophage infiltration in CS group compared to NC group (original magnification: 400×; scale bar: 100 μm). k F4/80-positive cells are counted equivalent infiltration of macrophages. l, m IHC staining analyses the expression of M1 associated molecular CD86, IL-6 and M2 associated molecular CD206, IL-10 in kidney tissues (original magnification: 400×, scale bar: 100 μm). n Representative confocal microscopy images of sections from kidneys harvested in NC and CS group mice stained for iNOS (green), F4/80 (red) and DAPI (blue) (scale bar: 100 μm). For statistical analysis, an unpaired two-tailed Student’s t test was used. Data are expressed as mean ± SD. n = 6. **P < 0.01, ***P < 0.001.